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6WA2

Crystal structure of EGFR(T790M/V948R) in complex with LN3753

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
C0004672molecular_functionprotein kinase activity
C0004713molecular_functionprotein tyrosine kinase activity
C0005524molecular_functionATP binding
C0006468biological_processprotein phosphorylation
D0004672molecular_functionprotein kinase activity
D0004713molecular_functionprotein tyrosine kinase activity
D0005524molecular_functionATP binding
D0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue TOV D 1301
ChainResidue
DLEU718
DMET790
DGLN791
DMET793
DCYS797
DARG841
DLEU844
DTHR854
DASP855
DPHE856
DLEU858
DVAL726
DALA743
DLYS745
DMET766
DCYS775
DARG776
DLEU777
DLEU788

site_idAC2
Number of Residues21
Detailsbinding site for residue TOV A 1301
ChainResidue
ALEU718
AVAL726
AALA743
ALYS745
AMET766
ACYS775
AARG776
ALEU777
ALEU788
AMET790
AGLN791
AMET793
APRO794
AGLY796
AARG841
AASN842
ALEU844
AASP855
APHE856
ALEU858
AHOH1423

site_idAC3
Number of Residues4
Detailsbinding site for residue CL A 1302
ChainResidue
AGLY721
APHE723
AGLY724
ALYS745

site_idAC4
Number of Residues3
Detailsbinding site for residue CL B 1201
ChainResidue
BGLY721
BPHE723
BLYS745

site_idAC5
Number of Residues19
Detailsbinding site for residue TOV B 1202
ChainResidue
BVAL726
BALA743
BLYS745
BMET766
BCYS775
BARG776
BLEU777
BMET790
BGLN791
BMET793
BPRO794
BGLY796
BARG841
BLEU844
BTHR854
BASP855
BPHE856
BLEU858
BHOH1350

site_idAC6
Number of Residues3
Detailsbinding site for residue CL C 1201
ChainResidue
CGLY721
CPHE723
CLYS745

site_idAC7
Number of Residues20
Detailsbinding site for residue TOV C 1202
ChainResidue
CLEU718
CVAL726
CALA743
CLYS745
CMET766
CCYS775
CARG776
CLEU777
CLEU788
CMET790
CGLN791
CMET793
CGLY796
CARG841
CASN842
CLEU844
CASP855
CPHE856
CLEU858
CHOH1328

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues28
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK
ChainResidueDetails
DLEU718-LYS745

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV
ChainResidueDetails
DLEU833-VAL845

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
DASP837
AASP837
BASP837
CASP837

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
ChainResidueDetails
DLEU718
ALEU718
BLEU718
CLEU718

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
ChainResidueDetails
DLYS745
ALYS745
BLYS745
CLYS745

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
ChainResidueDetails
DMET790
AMET790
BMET790
CMET790

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41
ChainResidueDetails
CASP855
DASP855
AASP855
BASP855

site_idSWS_FT_FI6
Number of Residues4
DetailsSITE: Important for interaction with PIK3C2B
ChainResidueDetails
BTYR1016
CTYR1016
DTYR1016
ATYR1016

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:3138233, ECO:0007744|PubMed:18691976
ChainResidueDetails
ASER695
DSER695
BSER695
CSER695

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674
ChainResidueDetails
DLYS745
ALYS745
BLYS745
CLYS745

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:23774213
ChainResidueDetails
DTYR869
ATYR869
BTYR869
CTYR869

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16083266, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
ChainResidueDetails
DSER991
ASER991
BSER991
CSER991

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
DSER995
ASER995
BSER995
CSER995

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0007744|PubMed:18669648
ChainResidueDetails
DTYR998
ATYR998
BTYR998
CTYR998

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19563760, ECO:0000269|PubMed:23774213
ChainResidueDetails
ATYR1016
DTYR1016
BTYR1016
CTYR1016

site_idSWS_FT_FI14
Number of Residues16
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:33996800
ChainResidueDetails
DLYS716
DLYS737
BLYS716
CLYS867
DLYS754
DLYS867
ALYS716
ALYS737
ALYS754
ALYS867
BLYS737
BLYS754
BLYS867
CLYS716
CLYS737
CLYS754

site_idSWS_FT_FI15
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144
ChainResidueDetails
DLYS929
DLYS970
ALYS929
ALYS970
BLYS929
BLYS970
CLYS929
CLYS970

site_idSWS_FT_FI16
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800
ChainResidueDetails
DLYS757
DLYS960
ALYS757
ALYS960
BLYS757
BLYS960
CLYS757
CLYS960

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PDB entries from 2024-06-12

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