6W8J
Structure of DNMT3A (R882H) in complex with CAG DNA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | DNA (cytosine-5)-methyltransferase 3A | polymer | 285 | 32696.7 | 2 | UniProt (Q9Y6K1) Pfam (PF00145) In PDB | Homo sapiens (Human) | Dnmt3a,DNA methyltransferase HsaIIIA,M.HsaIIIA |
2 | B, C | DNA (cytosine-5)-methyltransferase 3-like | polymer | 209 | 24163.7 | 2 | UniProt (Q9UJW3) In PDB | Homo sapiens (Human) | |
3 | E, F | CAG DNA (25-MER) | polymer | 25 | 7699.0 | 2 | synthetic construct | ||
4 | A, D | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
5 | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A, D: 628 - 912 (UniProt: Q9Y6K1)
PDB | External Database | Details |
---|---|---|
His 882 | Arg 882 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 129118.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 768.8 | |
All* | Total formula weight | 129887.5 |