6W8H

H-PGDS complexed with inhibitor 1Y

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Hematopoietic prostaglandin D synthase	polymer	213	25182.8	2	UniProt (O60760) Pfam (PF02798) Pfam (PF14497) In PDB	Homo sapiens (Human)	H-PGDS,GST class-sigma,Glutathione S-transferase,Glutathione-dependent PGD synthase,Glutathione-requiring prostaglandin D synthase,Prostaglandin-H2 D-isomerase
2	A, C	GLUTATHIONE	non-polymer		307.3	2	Chemie (GSH)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	A, C	7-cyclopropyl-N-[trans-4-(2-hydroxypropan-2-yl)cyclohexyl]-1,8-naphthyridine-3-carboxamide	non-polymer		353.5	2	Chemie (TJG)
5		water	water		18.0	102	Chemie (HOH)

Sequence modifications

A, C: 1 - 199 (UniProt: O60760)

PDB	External Database	Details
Met -13	-	initiating methionine
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50365.6
Non-Polymers*	Number of molecules	5
	Total formula weight	1383.6
All*	Total formula weight	51749.3

*Water molecules are not included.