6W8H

H-PGDS complexed with inhibitor 1Y

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001516	biological_process	prostaglandin biosynthetic process
A	0004364	molecular_function	glutathione transferase activity
A	0004667	molecular_function	prostaglandin-D synthase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0007165	biological_process	signal transduction
A	0007626	biological_process	locomotory behavior
A	0016740	molecular_function	transferase activity
A	0016853	molecular_function	isomerase activity
A	0019371	biological_process	cyclooxygenase pathway
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0001516	biological_process	prostaglandin biosynthetic process
C	0004364	molecular_function	glutathione transferase activity
C	0004667	molecular_function	prostaglandin-D synthase activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0007165	biological_process	signal transduction
C	0007626	biological_process	locomotory behavior
C	0016740	molecular_function	transferase activity
C	0016853	molecular_function	isomerase activity
C	0019371	biological_process	cyclooxygenase pathway
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue GSH A 201

Chain	Residue
A	TYR8
A	TJG203
A	HOH315
C	ASP97
A	ARG14
A	TRP39
A	LYS43
A	LYS50
A	ILE51
A	PRO52
A	GLN63
A	SER64

---

site_id	AC2
Number of Residues	2
Details	binding site for residue EDO A 202

Chain	Residue
A	GLN28
A	TYR29

---

site_id	AC3
Number of Residues	10
Details	binding site for residue TJG A 203

Chain	Residue
A	PHE9
A	MET11
A	GLY13
A	ARG14
A	GLN36
A	TRP39
A	TRP104
A	TYR152
A	GSH201
A	HOH304

---

site_id	AC4
Number of Residues	12
Details	binding site for residue GSH C 201

Chain	Residue
A	ASP97
C	TYR8
C	ARG14
C	TRP39
C	LYS43
C	LYS50
C	ILE51
C	PRO52
C	GLN63
C	SER64
C	TJG202
C	HOH328

---

site_id	AC5
Number of Residues	9
Details	binding site for residue TJG C 202

Chain	Residue
C	PHE9
C	MET11
C	GLY13
C	ARG14
C	GLN36
C	TRP104
C	TYR152
C	GSH201
C	HOH318

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	154
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	236
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12627223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15113825","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16547010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18341273","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19939518","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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