6W87
K2P2.1 (TREK-1):ML335 complex, 50 mM K+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium channel subfamily K member 2 | polymer | 312 | 34303.9 | 2 | UniProt (P97438) Pfam (PF07885) | Mus musculus (Mouse) | Outward rectifying potassium channel protein TREK-1,TREK-1 K(+) channel subunit,Two pore potassium channel TPKC1 |
| 2 | C, D, F, G, H (A) | POTASSIUM ION | non-polymer | 39.1 | 5 | Chemie (K) | |||
| 3 | E, R (A, B) | N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide | non-polymer | 373.3 | 2 | Chemie (Q6F) | |||
| 4 | I, S, T, U (A, B) | DODECANE | non-polymer | 170.3 | 4 | Chemie (D12) | |||
| 5 | J, Y, Z (A, B) | UNDECANE | non-polymer | 156.3 | 3 | Chemie (UND) | |||
| 6 | K (A) | DECANE | non-polymer | 142.3 | 1 | Chemie (D10) | |||
| 7 | L, M (A) | N-OCTANE | non-polymer | 114.2 | 2 | Chemie (OCT) | |||
| 8 | N, O, P, Q (A, B) | CADMIUM ION | non-polymer | 112.4 | 4 | Chemie (CD) | |||
| 9 | V, W, X (B) | HEXADECANE | non-polymer | 226.4 | 3 | Chemie (R16) | |||
| 10 | AA, BA, CA (B) | PENTANE | non-polymer | 72.1 | 3 | Chemie (LNK) |
Sequence modifications
A, B: 21 - 322 (UniProt: P97438)
| PDB | External Database | Details |
|---|---|---|
| Met 20 | - | expression tag |
| Arg 84 | Lys 99 | engineered mutation |
| Glu 85 | Gln 100 | engineered mutation |
| Lys 86 | Thr 101 | engineered mutation |
| Leu 88 | Ile 103 | engineered mutation |
| Arg 89 | Ala 104 | engineered mutation |
| Ala 90 | Gln 105 | engineered mutation |
| Pro 92 | Ala 107 | engineered mutation |
| Ser 95 | Asn 110 | engineered mutation |
| Asp 96 | Ser 111 | engineered mutation |
| Gln 97 | Thr 112 | engineered mutation |
| Ala 119 | Asn 134 | engineered mutation |
| Ala 300 | Ser 315 | engineered mutation |
| Ala 306 | Glu 321 | engineered mutation |
| Ser 323 | - | expression tag |
| Asn 324 | - | expression tag |
| Ser 325 | - | expression tag |
| Leu 326 | - | expression tag |
| Glu 327 | - | expression tag |
| Val 328 | - | expression tag |
| Leu 329 | - | expression tag |
| Phe 330 | - | expression tag |
| Gln 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68607.9 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 3808.4 | |
| All* | Total formula weight | 72416.3 |
