6W6D
Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with SGC6870 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein arginine N-methyltransferase 6 | polymer | 376 | 42074.6 | 1 | UniProt (Q96LA8) Pfam (PF13649) Pfam (PF22528) In PDB | Homo sapiens (Human) | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6,Histone-arginine N-methyltransferase PRMT6 |
| 2 | A | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 3 | A | (5R)-4-(5-bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one | non-polymer | 469.4 | 1 | Chemie (T9A) | |||
| 4 | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A: 1 - 375 (UniProt: Q96LA8)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Val 194 | Ala 194 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42074.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 853.8 | |
| All* | Total formula weight | 42928.4 |
