6W5H

1.85 A resolution structure of Norovirus 3CL protease in complex with inhibitor 5d

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	3C-LIKE PROTEASE	polymer	187	19994.9	4	UniProt (Q83883)	Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US)
2	E, F, G, H (A, B, C, D)	2-(3-chlorophenyl)-2-methylpropyl [(2S)-3-cyclohexyl-1-({(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-1-oxopropan-2-yl]carbamate	non-polymer		522.1	4	BIRD (PRD_002452) Chemie (TKP)
3	I, J, K, L (A, B, C, D)	water	water		18.0	147	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 181 (UniProt: Q83883)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	79979.7
Non-Polymers*	Number of molecules	4
	Total formula weight	2088.3
All*	Total formula weight	82068.0

*Water molecules are not included.