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6W5H

1.85 A resolution structure of Norovirus 3CL protease in complex with inhibitor 5d

Functional Information from GO Data
ChainGOidnamespacecontents
A0004197molecular_functioncysteine-type endopeptidase activity
A0006508biological_processproteolysis
B0004197molecular_functioncysteine-type endopeptidase activity
B0006508biological_processproteolysis
C0004197molecular_functioncysteine-type endopeptidase activity
C0006508biological_processproteolysis
D0004197molecular_functioncysteine-type endopeptidase activity
D0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue TKP A 201
ChainResidue
AHIS30
AVAL168
AHOH312
AHOH332
CSER106
AGLU54
AGLN110
ATHR134
ACYS139
AHIS157
AALA158
AALA159
AALA160

site_idAC2
Number of Residues21
Detailsbinding site for Di-peptide TKP B 201 and CYS B 139
ChainResidue
BGLY15
BTRP16
BHIS30
BGLU54
BILE109
BGLN110
BVAL114
BTHR134
BGLY137
BASP138
BGLY140
BALA141
BHIS157
BALA158
BALA159
BALA160
BLYS162
BVAL168
BHOH312
BHOH321
BHOH329

site_idAC3
Number of Residues19
Detailsbinding site for Di-peptide TKP C 201 and CYS C 139
ChainResidue
CGLY15
CTRP16
CHIS30
CGLU54
CILE109
CGLN110
CARG112
CTHR134
CGLY137
CASP138
CGLY140
CALA141
CHIS157
CALA158
CALA159
CALA160
CVAL168
CHOH312
CHOH322

site_idAC4
Number of Residues21
Detailsbinding site for Di-peptide TKP D 201 and CYS D 139
ChainResidue
BALA105
BSER106
DGLY15
DTRP16
DHIS30
DVAL31
DGLU54
DGLN110
DARG112
DTHR134
DGLY137
DASP138
DGLY140
DALA141
DHIS157
DALA158
DALA159
DALA160
DLYS162
DVAL168
DHOH318

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: For 3CLpro activity => ECO:0000255|PROSITE-ProRule:PRU00870, ECO:0000269|PubMed:16641296, ECO:0000269|PubMed:23365454
ChainResidueDetails
AHIS30
DHIS30
DGLU54
DCYS139
AGLU54
ACYS139
BHIS30
BGLU54
BCYS139
CHIS30
CGLU54
CCYS139

site_idSWS_FT_FI2
Number of Residues4
DetailsSITE: Cleavage; by 3CLpro => ECO:0000305|PubMed:17554035, ECO:0000305|PubMed:20976190
ChainResidueDetails
AGLU181
BGLU181
CGLU181
DGLU181

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PDB entries from 2024-08-21

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