6W5H
1.85 A resolution structure of Norovirus 3CL protease in complex with inhibitor 5d
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue TKP A 201 |
| Chain | Residue |
| A | HIS30 |
| A | VAL168 |
| A | HOH312 |
| A | HOH332 |
| C | SER106 |
| A | GLU54 |
| A | GLN110 |
| A | THR134 |
| A | CYS139 |
| A | HIS157 |
| A | ALA158 |
| A | ALA159 |
| A | ALA160 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide TKP B 201 and CYS B 139 |
| Chain | Residue |
| B | GLY15 |
| B | TRP16 |
| B | HIS30 |
| B | GLU54 |
| B | ILE109 |
| B | GLN110 |
| B | VAL114 |
| B | THR134 |
| B | GLY137 |
| B | ASP138 |
| B | GLY140 |
| B | ALA141 |
| B | HIS157 |
| B | ALA158 |
| B | ALA159 |
| B | ALA160 |
| B | LYS162 |
| B | VAL168 |
| B | HOH312 |
| B | HOH321 |
| B | HOH329 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide TKP C 201 and CYS C 139 |
| Chain | Residue |
| C | GLY15 |
| C | TRP16 |
| C | HIS30 |
| C | GLU54 |
| C | ILE109 |
| C | GLN110 |
| C | ARG112 |
| C | THR134 |
| C | GLY137 |
| C | ASP138 |
| C | GLY140 |
| C | ALA141 |
| C | HIS157 |
| C | ALA158 |
| C | ALA159 |
| C | ALA160 |
| C | VAL168 |
| C | HOH312 |
| C | HOH322 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide TKP D 201 and CYS D 139 |
| Chain | Residue |
| B | ALA105 |
| B | SER106 |
| D | GLY15 |
| D | TRP16 |
| D | HIS30 |
| D | VAL31 |
| D | GLU54 |
| D | GLN110 |
| D | ARG112 |
| D | THR134 |
| D | GLY137 |
| D | ASP138 |
| D | GLY140 |
| D | ALA141 |
| D | HIS157 |
| D | ALA158 |
| D | ALA159 |
| D | ALA160 |
| D | LYS162 |
| D | VAL168 |
| D | HOH318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"description":"For 3CLpro activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00870","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16641296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23365454","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
