6W3I
Crystal structure of a FAM46C mutant in complex with Plk4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Terminal nucleotidyltransferase 5C | polymer | 345 | 39768.4 | 1 | UniProt (Q5VWP2) Pfam (PF07984) | Homo sapiens (Human) | Non-canonical poly(A) polymerase FAM46C |
| 2 | B (B) | Serine/threonine-protein kinase PLK4 | polymer | 223 | 25869.6 | 1 | UniProt (O00444) Pfam (PF18190) Pfam (PF18409) | Homo sapiens (Human) | Polo-like kinase 4,PLK-4,Serine/threonine-protein kinase 18,Serine/threonine-protein kinase Sak |
Sequence modifications
A: 14 - 358 (UniProt: Q5VWP2)
| PDB | External Database | Details |
|---|---|---|
| Gln 166 | Glu 166 | engineered mutation |
| Asp 193 | Phe 193 | engineered mutation |
| Asp 206 | Phe 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65638.0 | |
| All* | Total formula weight | 65638.0 |
