6W2Y

CryoEM Structure of GABAB1b Homodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Gamma-aminobutyric acid type B receptor subunit 1	polymer	829	94173.6	2	UniProt (Q9UBS5) Pfam (PF01094) Pfam (PF00003)	Homo sapiens (Human)	Gb1
2	C, D (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	E, F, J, K (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
4	G, L (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	H, M (A, B)	(1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate	non-polymer		746.0	2	Chemie (L9Q)
6	I, N (A, B)	[(2~{S})-3-[[(1~{S})-1-(3,4-dichlorophenyl)ethyl]amino]-2-oxidanyl-propyl]-(phenylmethyl)phosphinic acid	non-polymer		402.3	2	Chemie (SGG)

Sequence modifications

A, B: 30 - 844 (UniProt: Q9UBS5)

PDB	External Database	Details
Asp 22	-	expression tag
Tyr 23	-	expression tag
Lys 24	-	expression tag
Asp 25	-	expression tag
Asp 26	-	expression tag
Asp 27	-	expression tag
Asp 28	-	expression tag
Lys 29	-	expression tag
His 845	-	expression tag
His 846	-	expression tag
His 847	-	expression tag
His 848	-	expression tag
His 849	-	expression tag
His 850	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	188347.1
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	10
	Total formula weight	3230.0
All*	Total formula weight	192426.0

*Water molecules are not included.