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6W2J

CPS1 bound to allosteric inhibitor H3B-374

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Carbamoyl-phosphate synthase [ammonia], mitochondrialpolymer1500165128.52UniProt (P31327)
Pfam (PF00988)
Pfam (PF00117)
Pfam (PF02786)
Pfam (PF02787)
Pfam (PF02142)
Homo sapiens (Human)Carbamoyl-phosphate synthetase I,CPSase I
2C, F
(A, B)
(2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanonenon-polymer418.42Chemie (374)
3D, G
(A, B)
ZINC IONnon-polymer65.42Chemie (ZN)
4E
(A)
1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
5H, I
(A, B)
waterwater18.0136Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight330257.1
Non-Polymers*Number of molecules5
Total formula weight1029.8
All*Total formula weight331286.8
*Water molecules are not included.

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PDB entries from 2025-07-30

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