6VXZ

SthK P300A cyclic nucleotide-gated potassium channel in the closed state, in complex with cAMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	SthK	polymer	456	51092.5	4	UniProt (G0GA88) Pfam (PF00520) Pfam (PF07885) Pfam (PF00027) In PDB	Spirochaeta thermophila (strain ATCC 700085 / DSM 6578 / Z-1203)
2	A, B, C, D	ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE	non-polymer		329.2	4	Chemie (CMP)
3	D, A, B, C	(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate	non-polymer		749.0	24	Chemie (PGW)

Sequence modifications

A, B, C, D: 1 - 420 (UniProt: G0GA88)

PDB	External Database	Details
Met -18	-	expression tag
Ala -17	-	expression tag
Lys -16	-	expression tag
Asp -15	-	expression tag
Ile -14	-	expression tag
Gly -13	-	expression tag
Ile -12	-	expression tag
Asn -11	-	expression tag
Ser -10	-	expression tag
Asp -9	-	expression tag
Pro -8	-	expression tag
Asn -7	-	expression tag
Ser -6	-	expression tag
Ser -5	-	expression tag
Ser -4	-	expression tag
Val -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
Leu 0	-	expression tag
Ala 300	Pro 300	engineered mutation
Leu 421	-	expression tag
Glu 422	-	expression tag
Ser 423	-	expression tag
Ser 424	-	expression tag
Gly 425	-	expression tag
Leu 426	-	expression tag
Val 427	-	expression tag
Pro 428	-	expression tag
Arg 429	-	expression tag
Gly 430	-	expression tag
Ser 431	-	expression tag
Val 432	-	expression tag
Lys 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	204370.2
Non-Polymers*	Number of molecules	28
	Total formula weight	19293.0
All*	Total formula weight	223663.1

*Water molecules are not included.