Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6VXZ

SthK P300A cyclic nucleotide-gated potassium channel in the closed state, in complex with cAMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0044877	molecular_function	protein-containing complex binding
A	0098655	biological_process	monoatomic cation transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0044877	molecular_function	protein-containing complex binding
B	0098655	biological_process	monoatomic cation transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0044877	molecular_function	protein-containing complex binding
C	0098655	biological_process	monoatomic cation transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0044877	molecular_function	protein-containing complex binding
D	0098655	biological_process	monoatomic cation transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CMP A 501

Chain	Residue
A	TYR357
A	GLY367
A	GLU368
A	MET369
A	ARG377
A	THR378

site_id	AC2
Number of Residues	1
Details	binding site for residue PGW A 502

Chain	Residue
A	GLY167

site_id	AC3
Number of Residues	4
Details	binding site for residue PGW A 503

Chain	Residue
A	TYR170
A	PGW507
A	PHE36
A	ALA166

site_id	AC4
Number of Residues	5
Details	binding site for residue PGW A 504

Chain	Residue
A	SER102
A	SER105
A	LEU109
A	GLY150
A	SER157

site_id	AC5
Number of Residues	5
Details	binding site for residue PGW A 505

Chain	Residue
A	TYR211
A	LEU221
B	PHE143
B	ALA209
B	LEU213

site_id	AC6
Number of Residues	4
Details	binding site for residue PGW A 506

Chain	Residue
A	ASN131
A	LEU138
A	LEU225
D	ARG233

site_id	AC7
Number of Residues	1
Details	binding site for residue PGW A 507

Chain	Residue
A	PGW503

site_id	AC8
Number of Residues	6
Details	binding site for residue CMP B 501

Chain	Residue
B	TYR357
B	GLY367
B	GLU368
B	MET369
B	ARG377
B	THR378

site_id	AC9
Number of Residues	1
Details	binding site for residue PGW B 502

Chain	Residue
B	GLY167

site_id	AD1
Number of Residues	4
Details	binding site for residue PGW B 503

Chain	Residue
B	PHE36
B	ALA166
B	TYR170
B	PGW507

site_id	AD2
Number of Residues	5
Details	binding site for residue PGW B 504

Chain	Residue
B	SER102
B	SER105
B	LEU109
B	GLY150
B	SER157

site_id	AD3
Number of Residues	5
Details	binding site for residue PGW B 505

Chain	Residue
B	TYR211
B	LEU221
C	PHE143
C	ALA209
C	LEU213

site_id	AD4
Number of Residues	4
Details	binding site for residue PGW B 506

Chain	Residue
A	ARG233
B	ASN131
B	LEU138
B	LEU225

site_id	AD5
Number of Residues	1
Details	binding site for residue PGW B 507

Chain	Residue
B	PGW503

site_id	AD6
Number of Residues	6
Details	binding site for residue CMP C 501

Chain	Residue
C	TYR357
C	GLY367
C	GLU368
C	MET369
C	ARG377
C	THR378

site_id	AD7
Number of Residues	1
Details	binding site for residue PGW C 502

Chain	Residue
C	GLY167

site_id	AD8
Number of Residues	4
Details	binding site for residue PGW C 503

Chain	Residue
C	PHE36
C	ALA166
C	TYR170
C	PGW507

site_id	AD9
Number of Residues	5
Details	binding site for residue PGW C 504

Chain	Residue
C	SER102
C	SER105
C	LEU109
C	GLY150
C	SER157

site_id	AE1
Number of Residues	5
Details	binding site for residue PGW C 505

Chain	Residue
C	TYR211
C	LEU221
D	PHE143
D	ALA209
D	LEU213

site_id	AE2
Number of Residues	4
Details	binding site for residue PGW C 506

Chain	Residue
B	ARG233
C	ASN131
C	LEU138
C	LEU225

site_id	AE3
Number of Residues	1
Details	binding site for residue PGW C 507

Chain	Residue
C	PGW503

site_id	AE4
Number of Residues	6
Details	binding site for residue CMP D 501

Chain	Residue
D	TYR357
D	GLY367
D	GLU368
D	MET369
D	ARG377
D	THR378

site_id	AE5
Number of Residues	1
Details	binding site for residue PGW D 502

Chain	Residue
D	GLY167

site_id	AE6
Number of Residues	4
Details	binding site for residue PGW D 503

Chain	Residue
D	PHE36
D	ALA166
D	TYR170
D	PGW507

site_id	AE7
Number of Residues	5
Details	binding site for residue PGW D 504

Chain	Residue
D	SER102
D	SER105
D	LEU109
D	GLY150
D	SER157

site_id	AE8
Number of Residues	5
Details	binding site for residue PGW D 505

Chain	Residue
A	PHE143
A	ALA209
A	LEU213
D	TYR211
D	LEU221

site_id	AE9
Number of Residues	4
Details	binding site for residue PGW D 506

Chain	Residue
C	ARG233
D	ASN131
D	LEU138
D	LEU225

site_id	AF1
Number of Residues	1
Details	binding site for residue PGW D 507

Chain	Residue
D	PGW503

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrAGEmGSdVYFInrG

Chain	Residue	Details
A	ILE328-GLY344

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEmALilrap......RTAtVrA

Chain	Residue	Details
A	PHE366-ALA383

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)