6VW2

Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Islet amyloid polypeptide (SUMO-tagged)	polymer	155	17274.3	10	UniProt (Q12306) UniProt (P10997) Pfam (PF00240) Pfam (PF00214)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	Amylin,Diabetes-associated peptide,DAP,Insulinoma amyloid peptide

Sequence modifications

A, B, C, D, E, F, G, H, I, J: -96 - 0 (UniProt: Q12306)

PDB	External Database	Details
Met -117	-	initiating methionine
Gly -116	-	expression tag
Ser -115	-	expression tag
Ser -114	-	expression tag
His -113	-	expression tag
His -112	-	expression tag
His -111	-	expression tag
His -110	-	expression tag
His -109	-	expression tag
His -108	-	expression tag
Gly -107	-	expression tag
Ser -106	-	expression tag
Gly -105	-	expression tag
Leu -104	-	expression tag
Val -103	-	expression tag
Pro -102	-	expression tag
Arg -101	-	expression tag
Gly -100	-	expression tag
Ser -99	-	expression tag
Ala -98	-	expression tag
Ser -97	-	expression tag

A, B, C, D, E, F, G, H, I, J: 1 - 37 (UniProt: P10997)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	172742.7
All*	Total formula weight	172742.7

*Water molecules are not included.