6VW2

Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000794	cellular_component	condensed nuclear chromosome
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005940	cellular_component	septin ring
A	0016925	biological_process	protein sumoylation
A	0031386	molecular_function	protein tag activity
A	0042802	molecular_function	identical protein binding
A	0044389	molecular_function	ubiquitin-like protein ligase binding
B	0000794	cellular_component	condensed nuclear chromosome
B	0005179	molecular_function	hormone activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005940	cellular_component	septin ring
B	0016925	biological_process	protein sumoylation
B	0031386	molecular_function	protein tag activity
B	0042802	molecular_function	identical protein binding
B	0044389	molecular_function	ubiquitin-like protein ligase binding
C	0000794	cellular_component	condensed nuclear chromosome
C	0005179	molecular_function	hormone activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005940	cellular_component	septin ring
C	0016925	biological_process	protein sumoylation
C	0031386	molecular_function	protein tag activity
C	0042802	molecular_function	identical protein binding
C	0044389	molecular_function	ubiquitin-like protein ligase binding
D	0000794	cellular_component	condensed nuclear chromosome
D	0005179	molecular_function	hormone activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005940	cellular_component	septin ring
D	0016925	biological_process	protein sumoylation
D	0031386	molecular_function	protein tag activity
D	0042802	molecular_function	identical protein binding
D	0044389	molecular_function	ubiquitin-like protein ligase binding
E	0000794	cellular_component	condensed nuclear chromosome
E	0005179	molecular_function	hormone activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005940	cellular_component	septin ring
E	0016925	biological_process	protein sumoylation
E	0031386	molecular_function	protein tag activity
E	0042802	molecular_function	identical protein binding
E	0044389	molecular_function	ubiquitin-like protein ligase binding
F	0000794	cellular_component	condensed nuclear chromosome
F	0005179	molecular_function	hormone activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005940	cellular_component	septin ring
F	0016925	biological_process	protein sumoylation
F	0031386	molecular_function	protein tag activity
F	0042802	molecular_function	identical protein binding
F	0044389	molecular_function	ubiquitin-like protein ligase binding
G	0000794	cellular_component	condensed nuclear chromosome
G	0005179	molecular_function	hormone activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005940	cellular_component	septin ring
G	0016925	biological_process	protein sumoylation
G	0031386	molecular_function	protein tag activity
G	0042802	molecular_function	identical protein binding
G	0044389	molecular_function	ubiquitin-like protein ligase binding
H	0000794	cellular_component	condensed nuclear chromosome
H	0005179	molecular_function	hormone activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005940	cellular_component	septin ring
H	0016925	biological_process	protein sumoylation
H	0031386	molecular_function	protein tag activity
H	0042802	molecular_function	identical protein binding
H	0044389	molecular_function	ubiquitin-like protein ligase binding
I	0000794	cellular_component	condensed nuclear chromosome
I	0005179	molecular_function	hormone activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005940	cellular_component	septin ring
I	0016925	biological_process	protein sumoylation
I	0031386	molecular_function	protein tag activity
I	0042802	molecular_function	identical protein binding
I	0044389	molecular_function	ubiquitin-like protein ligase binding
J	0000794	cellular_component	condensed nuclear chromosome
J	0005179	molecular_function	hormone activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005940	cellular_component	septin ring
J	0016925	biological_process	protein sumoylation
J	0031386	molecular_function	protein tag activity
J	0042802	molecular_function	identical protein binding
J	0044389	molecular_function	ubiquitin-like protein ligase binding

Functional Information from PROSITE/UniProt

site_id	PS00258
Number of Residues	15
Details	CALCITONIN Calcitonin / CGRP / IAPP family signature. CNT.ATCAtqrLanfL

Chain	Residue	Details
A	CYS2-LEU16

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950

Chain	Residue	Details
A	SER-95
J	SER-95
B	SER-95
C	SER-95
D	SER-95
E	SER-95
F	SER-95
G	SER-95
H	SER-95
I	SER-95

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358

Chain	Residue	Details
A	SER-93
J	SER-93
B	SER-93
C	SER-93
D	SER-93
E	SER-93
F	SER-93
G	SER-93
H	SER-93
I	SER-93

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: Tyrosine amide => ECO:0000269|PubMed:2651160, ECO:0000269|PubMed:3053705

Chain	Residue	Details
A	TYR37
J	TYR37
B	TYR37
C	TYR37
D	TYR37
E	TYR37
F	TYR37
G	TYR37
H	TYR37
I	TYR37

---