6VV9
Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB300
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 161 | 17893.3 | 2 | UniProt (A5U6B6) Pfam (PF00186) | Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) | |
| 2 | C, H (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, J (A, B) | 5-[4-(1H-indol-3-yl)butoxy]-1-phenyl-1H-pyrazole-4-carboxylic acid | non-polymer | 375.4 | 2 | Chemie (RQ1) | |||
| 4 | E, F, K, L, M (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 5 | G, I (B) | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 159 (UniProt: A5U6B6)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Thr 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35786.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2834.4 | |
| All* | Total formula weight | 38621.0 |
