Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 29 |
Details | binding site for residue NDP A 201 |
Chain | Residue |
A | TRP6 |
A | ARG45 |
A | THR46 |
A | LEU65 |
A | SER66 |
A | ARG67 |
A | GLN68 |
A | GLY80 |
A | ILE94 |
A | GLY95 |
A | GLY96 |
A | ALA7 |
A | GLY97 |
A | GLN98 |
A | VAL99 |
A | TYR100 |
A | LEU102 |
A | ALA126 |
A | RQ1202 |
A | PO4204 |
A | HOH317 |
A | HOH329 |
A | ILE14 |
A | GLY15 |
A | GLY18 |
A | ASP19 |
A | ILE20 |
A | GLY43 |
A | ARG44 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue RQ1 A 202 |
Chain | Residue |
A | GLN28 |
A | PHE31 |
A | ARG32 |
A | LEU50 |
A | VAL54 |
A | LEU57 |
A | ARG60 |
A | ILE94 |
A | NDP201 |
A | HOH308 |
site_id | AC3 |
Number of Residues | 1 |
Details | binding site for residue PO4 A 203 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue PO4 A 204 |
Chain | Residue |
A | ARG67 |
A | NDP201 |
A | HOH301 |
A | HOH329 |
B | ARG67 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue CO B 301 |
Chain | Residue |
A | HIS38 |
A | HOH312 |
B | HIS157 |
B | HOH407 |
B | HOH409 |
site_id | AC6 |
Number of Residues | 28 |
Details | binding site for residue NDP B 302 |
Chain | Residue |
B | TRP6 |
B | ALA7 |
B | ILE14 |
B | GLY15 |
B | ARG16 |
B | GLY18 |
B | ASP19 |
B | ILE20 |
B | GLY43 |
B | ARG44 |
B | ARG45 |
B | THR46 |
B | LEU65 |
B | SER66 |
B | ARG67 |
B | GLN68 |
B | GLY80 |
B | ILE94 |
B | GLY96 |
B | GLY97 |
B | GLN98 |
B | VAL99 |
B | TYR100 |
B | ALA126 |
B | RQ1304 |
B | HOH408 |
B | HOH415 |
B | HOH429 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue CO B 303 |
Chain | Residue |
A | HOH334 |
B | HIS38 |
B | HOH424 |
B | HOH428 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue RQ1 B 304 |
Chain | Residue |
B | GLN28 |
B | PHE31 |
B | ARG32 |
B | LEU50 |
B | ARG60 |
B | ILE94 |
B | NDP302 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue PO4 B 305 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue PO4 B 306 |
Chain | Residue |
B | TRP142 |
B | ARG150 |
site_id | AD2 |
Number of Residues | 2 |
Details | binding site for residue PO4 B 307 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrggdIPWrlpe.DqahFreiT |
Chain | Residue | Details |
A | VAL13-THR35 | |