6VUM
Structure of nevanimibe-bound human tetrameric ACAT1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Sterol O-acyltransferase 1 | polymer | 558 | 65801.3 | 4 | UniProt (P35610) Pfam (PF03062) In PDB | Homo sapiens (Human) | Acyl-coenzyme A:cholesterol acyltransferase 1,ACAT-1,Cholesterol acyltransferase 1 |
2 | A, B, C, D | OLEIC ACID | non-polymer | 282.5 | 4 | Chemie (OLA) | |||
3 | A, B, C, D | CHOLESTEROL | non-polymer | 386.7 | 10 | Chemie (CLR) | |||
4 | A, B, C, D | nevanimibe | non-polymer | 421.6 | 4 | Chemie (ROV) | |||
5 | A, C | COENZYME A | non-polymer | 767.5 | 2 | Chemie (COA) | |||
6 | B, D | S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | non-polymer | 1032.0 | 2 | Chemie (3VV) |
Sequence modifications
A, B, C, D: 1 - 550 (UniProt: P35610)
PDB | External Database | Details |
---|---|---|
Asp 551 | - | expression tag |
Tyr 552 | - | expression tag |
Lys 553 | - | expression tag |
Asp 554 | - | expression tag |
Asp 555 | - | expression tag |
Asp 556 | - | expression tag |
Asp 557 | - | expression tag |
Lys 558 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 263205.0 | |
Non-Polymers* | Number of molecules | 22 |
Total formula weight | 10281.9 | |
All* | Total formula weight | 273486.9 |