6VUM
Structure of nevanimibe-bound human tetrameric ACAT1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Sterol O-acyltransferase 1 | polymer | 558 | 65801.3 | 4 | UniProt (P35610) Pfam (PF03062) | Homo sapiens (Human) | Acyl-coenzyme A:cholesterol acyltransferase 1,ACAT-1,Cholesterol acyltransferase 1 |
| 2 | E, K, P, V (A, B, C, D) | OLEIC ACID | non-polymer | 282.5 | 4 | Chemie (OLA) | |||
| 3 | F, G, H, M, N... (A, B, C, D) | CHOLESTEROL | non-polymer | 386.7 | 10 | Chemie (CLR) | |||
| 4 | I, O, T, Z (A, B, C, D) | nevanimibe | non-polymer | 421.6 | 4 | Chemie (ROV) | |||
| 5 | J, U (A, C) | COENZYME A | non-polymer | 767.5 | 2 | Chemie (COA) | |||
| 6 | L, W (B, D) | S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | non-polymer | 1032.0 | 2 | Chemie (3VV) |
Sequence modifications
A, B, C, D: 1 - 550 (UniProt: P35610)
| PDB | External Database | Details |
|---|---|---|
| Asp 551 | - | expression tag |
| Tyr 552 | - | expression tag |
| Lys 553 | - | expression tag |
| Asp 554 | - | expression tag |
| Asp 555 | - | expression tag |
| Asp 556 | - | expression tag |
| Asp 557 | - | expression tag |
| Lys 558 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 263205.0 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 10281.9 | |
| All* | Total formula weight | 273486.9 |
