6VRN

T cell receptor-p53-HLA-A2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	MHC class I antigen	polymer	293	33912.5	1	UniProt (Q861F7) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (A0A140T913) In PDB	Homo sapiens (Human)
2	B	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	D	T-cell receptor 38-10, alfa chain	polymer	212	23811.4	1		Homo sapiens (Human)
4	E	TCR repeptor 38-10, beta chain	polymer	245	27709.7	1		Homo sapiens (Human)
5	P	Cellular tumor antigen p53 peptide	polymer	9	1114.3	1	UniProt (P04637) In PDB	Homo sapiens (Human)	Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
6		water	water		18.0	294	Chemie (HOH)

Sequence modifications

A: 1 - 275 (UniProt: Q861F7)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 276	-	expression tag
Gly 277	-	expression tag
Gly 278	-	expression tag
Leu 279	-	expression tag
Asn 280	-	expression tag
Asp 281	-	expression tag
Ile 282	-	expression tag
Phe 283	-	expression tag
Glu 284	-	expression tag
Ala 285	-	expression tag
Gln 286	-	expression tag
Lys 287	-	expression tag
Ile 288	-	expression tag
Glu 289	-	expression tag
Trp 290	-	expression tag
His 291	-	expression tag
Glu 292	-	expression tag

B: 2 - 100 (UniProt: P61769)

PDB	External Database	Details
Met 1	-	initiating methionine

P: 1 - 9 (UniProt: P04637)

PDB	External Database	Details
His 8	Arg 175	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	98427.2
All*	Total formula weight	98427.2

*Water molecules are not included.