6VRH
Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent serotonin transporter | polymer | 630 | 70371.3 | 1 | UniProt (P31645) Pfam (PF03491) Pfam (PF00209) | Homo sapiens (Human) | SERT,5HT transporter,5HTT,Solute carrier family 6 member 4 |
| 2 | B (C) | 8B6 antibody, light chain | polymer | 214 | 23718.2 | 1 | UniProt (A0A0U5BC76) Pfam (PF07686) Pfam (PF07654) | Mus musculus (Mouse) | |
| 3 | C (B) | 8B6 antibody, heavy chain | polymer | 221 | 23688.4 | 1 | Mus musculus (Mouse) | ||
| 4 | D, G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | E (A) | Paroxetine | non-polymer | 329.4 | 1 | Chemie (8PR) | |||
| 6 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | H (A) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 117777.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1317.8 | |
| All* | Total formula weight | 119095.7 |
