6VRH
Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sodium-dependent serotonin transporter | polymer | 630 | 70371.3 | 1 | UniProt (P31645) Pfam (PF03491) Pfam (PF00209) In PDB | Homo sapiens (Human) | SERT,5HT transporter,5HTT,Solute carrier family 6 member 4 |
2 | C | 8B6 antibody, light chain | polymer | 214 | 23718.2 | 1 | UniProt (A0A0U5BC76) Pfam (PF07686) Pfam (PF07654) In PDB | Mus musculus (Mouse) | |
3 | B | 8B6 antibody, heavy chain | polymer | 221 | 23688.4 | 1 | Mus musculus (Mouse) | ||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
5 | A | Paroxetine | non-polymer | 329.4 | 1 | Chemie (8PR) | |||
6 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
7 | A | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 117777.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1317.8 | |
All* | Total formula weight | 119095.7 |