6VQ7
Mammalian V-ATPase from rat brain - composite model of rotational state 2 bound to ADP and SidK (built from focused refinement models)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | ATPase H+-transporting V1 subunit A | polymer | 617 | 68341.8 | 3 | UniProt (D4A133) Pfam (PF02874) Pfam (PF16886) Pfam (PF00006) Pfam (PF22919) | Rattus norvegicus (Rat) | RCG52629 |
| 2 | D, E, F (D, E, F) | V-type proton ATPase subunit B, brain isoform | polymer | 511 | 56611.6 | 3 | UniProt (P62815) Pfam (PF02874) Pfam (PF00006) Pfam (PF22919) | Rattus norvegicus (Rat) | V-ATPase subunit B 2,Endomembrane proton pump 58 kDa subunit,Vacuolar proton pump subunit B 2 |
| 3 | G (G) | V-type proton ATPase subunit C 1 | polymer | 382 | 43958.5 | 1 | UniProt (Q5FVI6) Pfam (PF03223) | Rattus norvegicus (Rat) | V-ATPase subunit C 1,Vacuolar proton pump subunit C 1 |
| 4 | H (H) | ATPase H+-transporting V1 subunit D | polymer | 247 | 28359.0 | 1 | UniProt (Q6P503) Pfam (PF01813) | Rattus norvegicus (Rat) | ATPase,H+ transporting,V1 subunit D,isoform CRA_c,lysosomal V1 subunit D |
| 5 | I, J, K (I, J, K) | V-type proton ATPase subunit E 1 | polymer | 226 | 26167.5 | 3 | UniProt (Q6PCU2) Pfam (PF01991) | Rattus norvegicus (Rat) | V-ATPase subunit E 1,Vacuolar proton pump subunit E 1 |
| 6 | L (L) | V-type proton ATPase subunit F | polymer | 119 | 13389.3 | 1 | UniProt (P50408) Pfam (PF01990) | Rattus norvegicus (Rat) | V-ATPase subunit F,V-ATPase 14 kDa subunit,Vacuolar proton pump subunit F |
| 7 | M, N, O (M, N, O) | V-type proton ATPase subunit G | polymer | 118 | 13690.5 | 3 | UniProt (Q8R2H0) Pfam (PF03179) | Rattus norvegicus (Rat) | |
| 8 | P, Q, R (Q, R, S) | Effector protein SidK | polymer | 301 | 34693.6 | 3 | UniProt (Q5ZWW6) | Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) | |
| 9 | S (a) | V-type proton ATPase 116 kDa subunit a isoform 1 | polymer | 838 | 96429.4 | 1 | UniProt (P25286) Pfam (PF01496) | Rattus norvegicus (Rat) | V-ATPase 116 kDa isoform a1,Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit,Vacuolar adenosine triphosphatase subunit Ac116,Vacuolar proton pump subunit 1,Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 |
| 10 | T (b) | ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a | polymer | 205 | 21618.6 | 1 | UniProt (B0K022) Pfam (PF00137) | Rattus norvegicus (Rat) | ATPase,H+ transporting,lysosomal V0 subunit B,Atp6v0b protein |
| 11 | U (c) | V-type proton ATPase subunit S1 | polymer | 463 | 51160.4 | 1 | UniProt (O54715) Pfam (PF05827) Pfam (PF20520) | Rattus norvegicus (Rat) | V-ATPase subunit S1,C7-1 protein,V-ATPase Ac45 subunit,V-ATPase S1 accessory protein,Vacuolar proton pump subunit S1 |
| 12 | V (d) | V-type proton ATPase subunit | polymer | 351 | 40341.9 | 1 | UniProt (Q5M7T6) Pfam (PF01992) | Rattus norvegicus (Rat) | |
| 13 | W (e) | V-type proton ATPase subunit e 2 | polymer | 81 | 9203.0 | 1 | UniProt (Q5EB76) Pfam (PF05493) | Rattus norvegicus (Rat) | V-ATPase subunit e 2,Vacuolar proton pump subunit e 2 |
| 14 | X (f) | Ribonuclease K | polymer | 98 | 11000.0 | 1 | UniProt (D3ZIM6) | Rattus norvegicus (Rat) | Rnasek protein |
| 15 | AA, BA, CA, DA, EA... (g, h, i, j, k...) | V-type proton ATPase 16 kDa proteolipid subunit | polymer | 155 | 15815.8 | 9 | UniProt (P63081) Pfam (PF00137) | Rattus norvegicus (Rat) | V-ATPase 16 kDa proteolipid subunit,Vacuolar proton pump 16 kDa proteolipid subunit |
| 16 | HA (p) | Renin receptor | polymer | 350 | 39118.6 | 1 | UniProt (Q6AXS4) Pfam (PF07850) | Rattus norvegicus (Rat) | ATPase H(+)-transporting lysosomal accessory protein 2,ATPase H(+)-transporting lysosomal-interacting protein 2,Renin/prorenin receptor |
| 17 | IA (B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 18 | JA (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
Q, R, S: 1 - 278 (UniProt: Q5ZWW6)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Asp 279 | - | expression tag |
| Tyr 280 | - | expression tag |
| Lys 281 | - | expression tag |
| Asp 282 | - | expression tag |
| His 283 | - | expression tag |
| Asp 284 | - | expression tag |
| Gly 285 | - | expression tag |
| Asp 286 | - | expression tag |
| Tyr 287 | - | expression tag |
| Lys 288 | - | expression tag |
| Asp 289 | - | expression tag |
| His 290 | - | expression tag |
| Asp 291 | - | expression tag |
| Ile 292 | - | expression tag |
| Asp 293 | - | expression tag |
| Tyr 294 | - | expression tag |
| Lys 295 | - | expression tag |
| Asp 296 | - | expression tag |
| Asp 297 | - | expression tag |
| Asp 298 | - | expression tag |
| Asp 299 | - | expression tag |
| Lys 300 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 34 |
| Total formula weight | 1095435.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 451.5 | |
| All* | Total formula weight | 1095887.4 |
