6VO5

Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4

Replaces:  6UHD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Histone acetyltransferase type B catalytic subunit	polymer	324	38139.3	2	UniProt (O14929) Pfam (PF10394) Pfam (PF21183) In PDB	Homo sapiens (Human)	Histone acetyltransferase 1
2	C, D	Histone H4	polymer	20	1943.3	2	UniProt (P62805) In PDB	Homo sapiens
3	A	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
4	A, B	ISOBUTYRYL-COENZYME A	non-polymer		837.6	2	Chemie (CO6)
5	A, B	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7	B, A	UNKNOWN ATOM OR ION	non-polymer			16	Chemie (UNX)
8		water	water		18.0	735	Chemie (HOH)

Sequence modifications

A, B: 20 - 341 (UniProt: O14929)

PDB	External Database	Details
Gly 18	-	expression tag
Ser 19	-	expression tag

C, D: 1 - 20 (UniProt: P62805)

PDB	External Database	Details
Ala 12	Lys 13	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80165.1
Non-Polymers*	Number of molecules	24
	Total formula weight	2202.7
All*	Total formula weight	82367.8

*Water molecules are not included.