6VO5
Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4
Replaces: 6UHDEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone acetyltransferase type B catalytic subunit | polymer | 324 | 38139.3 | 2 | UniProt (O14929) Pfam (PF10394) Pfam (PF21183) | Homo sapiens (Human) | Histone acetyltransferase 1 |
| 2 | C, D (C, D) | Histone H4 | polymer | 20 | 1943.3 | 2 | UniProt (P62805) | Homo sapiens | |
| 3 | E (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | F, R (A, B) | ISOBUTYRYL-COENZYME A | non-polymer | 837.6 | 2 | Chemie (CO6) | |||
| 5 | G, S, T (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | H, U (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 7 | AA, BA, I, J, K... (B, A) | UNKNOWN ATOM OR ION | non-polymer | 16 | Chemie (UNX) | ||||
| 8 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 735 | Chemie (HOH) |
Sequence modifications
A, B: 20 - 341 (UniProt: O14929)
C, D: 1 - 20 (UniProt: P62805)
| PDB | External Database | Details |
|---|---|---|
| Gly 18 | - | expression tag |
| Ser 19 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 12 | Lys 13 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 80165.1 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2202.7 | |
| All* | Total formula weight | 82367.8 |
