Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006325 | biological_process | chromatin organization |
| A | 0031509 | biological_process | subtelomeric heterochromatin formation |
| A | 0042393 | molecular_function | histone binding |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006325 | biological_process | chromatin organization |
| B | 0031509 | biological_process | subtelomeric heterochromatin formation |
| B | 0042393 | molecular_function | histone binding |
| C | 0000786 | cellular_component | nucleosome |
| C | 0003677 | molecular_function | DNA binding |
| D | 0000786 | cellular_component | nucleosome |
| D | 0003677 | molecular_function | DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 501 |
| Chain | Residue |
| A | ARG39 |
| A | PHE247 |
| A | HOH835 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | binding site for residue CO6 A 502 |
| Chain | Residue |
| A | GLN248 |
| A | GLY249 |
| A | GLN250 |
| A | GLY251 |
| A | HIS252 |
| A | GLY253 |
| A | ALA254 |
| A | ALA275 |
| A | PRO278 |
| A | SER279 |
| A | SER281 |
| A | TYR282 |
| A | LYS284 |
| A | LEU285 |
| A | PHE288 |
| A | HOH627 |
| A | HOH644 |
| A | HOH673 |
| A | HOH864 |
| A | PHE185 |
| A | ILE186 |
| A | VAL238 |
| A | MET241 |
| A | LEU242 |
| A | ILE243 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | ASP196 |
| A | HOH610 |
| A | HOH634 |
| A | HOH674 |
| B | ASP193 |
| B | ASP195 |
| C | LYS8 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | THR274 |
| A | ALA275 |
| A | PRO278 |
| A | ARG286 |
| A | GLN326 |
| A | HIS327 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | binding site for residue CO6 B 401 |
| Chain | Residue |
| B | PHE185 |
| B | ILE186 |
| B | VAL238 |
| B | SER239 |
| B | GLN240 |
| B | MET241 |
| B | LEU242 |
| B | ILE243 |
| B | GLN248 |
| B | GLY249 |
| B | GLN250 |
| B | GLY251 |
| B | HIS252 |
| B | GLY253 |
| B | ALA254 |
| B | GLU276 |
| B | ASP277 |
| B | PRO278 |
| B | SER279 |
| B | SER281 |
| B | TYR282 |
| B | LYS284 |
| B | LEU285 |
| B | PHE288 |
| B | HOH531 |
| B | HOH556 |
| B | HOH571 |
| B | HOH572 |
| B | HOH578 |
| B | HOH628 |
| B | HOH758 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | LEU143 |
| B | HIS144 |
| B | THR145 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | GLY140 |
| B | THR141 |
| B | LYS163 |
| B | ALA164 |
| B | ASP165 |
| B | HOH587 |
| B | HOH658 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | THR274 |
| B | ALA275 |
| B | PRO278 |
| B | ARG286 |
| B | HIS327 |
| B | HOH623 |
Functional Information from PROSITE/UniProt
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| C | GLY14-HIS18 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Region: {"description":"Interaction with histone H4 N-terminus","evidences":[{"source":"PubMed","id":"22615379","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Region: {"description":"Interaction with histone H4 N-terminus","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22615379","evidenceCode":"ECO:0000303"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22615379","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with histone H4 N-terminus","evidences":[{"source":"PubMed","id":"22615379","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"28143904","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]} |
