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6VNS

Crystal structure of TYK2 kinase with compound 13

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Non-receptor tyrosine-protein kinase TYK2polymer31836550.61UniProt (P29597)
Pfam (PF07714)
Homo sapiens (Human)
2B
(A)
(1R,2R)-2-cyano-N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamidenon-polymer412.41Chemie (R5D)
3C
(A)
waterwater18.0157Chemie (HOH)
Sequence modifications
A: 888 - 1182 (UniProt: P29597)
PDBExternal DatabaseDetails
Met 865-expression tag
Ala 866-expression tag
His 867-expression tag
His 868-expression tag
His 869-expression tag
His 870-expression tag
His 871-expression tag
His 872-expression tag
His 873-expression tag
His 874-expression tag
His 875-expression tag
His 876-expression tag
Gly 877-expression tag
Ala 878-expression tag
Leu 879-expression tag
Glu 880-expression tag
Val 881-expression tag
Leu 882-expression tag
Phe 883-expression tag
Gln 884-expression tag
Gly 885-expression tag
Pro 886-expression tag
Gly 887-expression tag
Ala 936Cys 936engineered mutation
Ala 969Gln 969engineered mutation
Ala 971Glu 971engineered mutation
Ala 972Lys 972engineered mutation
Ser 1016Ala 1016conflict
Ala 1142Cys 1142engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight36550.6
Non-Polymers*Number of molecules1
Total formula weight412.4
All*Total formula weight36963.0
*Water molecules are not included.

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PDB entries from 2024-11-20

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