6VNL

JAK2 JH1 in complex with SG3-179

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	D, B, C, A	Tyrosine-protein kinase JAK2	polymer	308	36455.4	4	UniProt (O60674) Pfam (PF07714) In PDB	Homo sapiens (Human)	Janus kinase 2,JAK-2
2	D, B, C, A	4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{N}-(1-methylpiperidin-4-yl)benzamide	non-polymer		604.1	4	Chemie (5W2)
3		water	water		18.0	215	Chemie (HOH)

Sequence modifications

D, B, C, A: 840 - 1132 (UniProt: O60674)

PDB	External Database	Details
His 825	-	expression tag
His 826	-	expression tag
His 827	-	expression tag
His 828	-	expression tag
His 829	-	expression tag
His 830	-	expression tag
His 831	-	expression tag
His 832	-	expression tag
Glu 833	-	expression tag
Asn 834	-	expression tag
Leu 835	-	expression tag
Tyr 836	-	expression tag
Phe 837	-	expression tag
Gln 838	-	expression tag
Gly 839	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	145821.8
Non-Polymers*	Number of molecules	4
	Total formula weight	2416.6
All*	Total formula weight	148238.3

*Water molecules are not included.