6VNL

JAK2 JH1 in complex with SG3-179

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 5W2 D 1201

Chain	Residue
D	LEU855
D	ASN981
D	LEU983
D	ASP994
D	GLY856
D	GLY858
D	ALA880
D	GLU930
D	LEU932
D	GLY935
D	ASP939
D	ARG980

---

site_id	AC2
Number of Residues	12
Details	binding site for residue 5W2 B 1201

Chain	Residue
B	LEU855
B	GLY856
B	GLY858
B	VAL863
B	ALA880
B	LYS882
B	MET929
B	GLU930
B	LEU932
B	GLY935
B	LEU983
B	ASP994

---

site_id	AC3
Number of Residues	14
Details	binding site for residue 5W2 C 1201

Chain	Residue
C	LEU855
C	GLY856
C	GLY858
C	VAL863
C	ALA880
C	GLU930
C	TYR931
C	LEU932
C	GLY935
C	ASP939
C	ARG980
C	ASN981
C	LEU983
C	ASP994

---

site_id	AC4
Number of Residues	14
Details	binding site for residue 5W2 A 1201

Chain	Residue
A	LEU855
A	GLY856
A	GLY858
A	ALA880
A	GLU930
A	TYR931
A	LEU932
A	GLY935
A	ASN981
A	LEU983
A	ASP994
A	HOH1306
A	HOH1352
C	ASP1004

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGNFGSVEmCrydplqdntgevv.....AVKK

Chain	Residue	Details
D	LEU855-LYS883

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLATRNILV

Chain	Residue	Details
D	TYR972-VAL984

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
D	ASP976
B	ASP976
C	ASP976
A	ASP976

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
D	LEU855
D	LYS882
B	LEU855
B	LYS882
C	LEU855
C	LYS882
A	LEU855
A	LYS882

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62120

Chain	Residue	Details
D	TYR868
A	TYR868
A	TYR966
A	TYR972
D	TYR966
D	TYR972
B	TYR868
B	TYR966
B	TYR972
C	TYR868
C	TYR966
C	TYR972

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16174768

Chain	Residue	Details
D	PTR1007
B	PTR1007
C	PTR1007
A	PTR1007

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:16174768

Chain	Residue	Details
D	TYR1008
B	TYR1008
C	TYR1008
A	TYR1008

---