6VMS
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40382.0 | 1 | UniProt (P10824) Pfam (PF00503) | Rattus norvegicus (Rat) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 82 | 9137.5 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (E) | scFv16 | polymer | 259 | 27784.9 | 1 | Homo sapiens (Human) | ||
| 5 | E (R) | Endolysin,D(2) dopamine receptor,D(2) dopamine receptor | polymer | 450 | 51384.1 | 1 | UniProt (D9IEF7) UniProt (P14416) Pfam (PF00001) | Enterobacteria phage T4 | Lysis protein,Lysozyme,Muramidase,Dopamine D2 receptor,Dopamine D2 receptor |
| 6 | F (R) | bromoergocryptine | non-polymer | 654.6 | 1 | Chemie (08Y) |
Sequence modifications
A: 1 - 354 (UniProt: P10824)
C: 2 - 71 (UniProt: P59768)
R: -132 - 27 (UniProt: D9IEF7)
R: 29 - 226 (UniProt: P14416)
R: 361 - 443 (UniProt: P14416)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ala 245 | Glu 245 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | expression tag |
| Gly -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -140 | - | expression tag |
| Tyr -139 | - | expression tag |
| Lys -138 | - | expression tag |
| Asp -137 | - | expression tag |
| Asp -136 | - | expression tag |
| Asp -135 | - | expression tag |
| Asp -134 | - | expression tag |
| Ala -133 | - | expression tag |
| Asn -114 | Asp 20 | conflict |
| Thr -80 | Cys 54 | conflict |
| Ala -37 | Cys 97 | conflict |
| Ala 28 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ile 205 | Thr 205 | conflict |
| Leu 222 | Arg 222 | conflict |
| Asn 226 | Lys 226 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 374 | Met 374 | conflict |
| Tyr 378 | Val 378 | conflict |
| Leu 381 | Val 381 | conflict |
| Ile 421 | Val 421 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 166105.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 654.6 | |
| All* | Total formula weight | 166760.0 |
