6VMK
Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, BA, D, EA, G... (W, C, F, I, N...) | Complement factor D | polymer | 228 | 24438.8 | 16 | UniProt (P00746) Pfam (PF00089) | Homo sapiens (Human) | Adipsin,C3 convertase activator,Properdin factor D |
| 2 | B, CA, E, FA, H... (L, A, D, G, J...) | Fab Y49R light chain | polymer | 214 | 23354.8 | 16 | Homo sapiens | ||
| 3 | AA, C, DA, F, GA... (M, B, E, H, K...) | Fab Y49R heavy chain | polymer | 223 | 23668.4 | 16 | Homo sapiens | ||
| 4 | AB, BB, CB, EB, GB... (F, I, N, Q, T...) | GLYCEROL | non-polymer | 92.1 | 16 | Chemie (GOL) | |||
| 5 | DB, FB, HB, JB, NB... (N, Q, T, X, g...) | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 6 | AC, AD, BC, BD, CC... (M, b, C, c, A...) | water | water | 18.0 | 1503 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 48 |
| Total formula weight | 1143392.1 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 2626.3 | |
| All* | Total formula weight | 1146018.4 |
