6VLH
HIV Integrase Core domain (IN) in complex with dimer-spanning ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrase | polymer | 164 | 17872.3 | 2 | UniProt (F2WR39) Pfam (PF00665) | Human immunodeficiency virus 1 (HIV-1) | |
| 2 | C, D, E, F, K... (A, B) | IODIDE ION | non-polymer | 126.9 | 6 | Chemie (IOD) | |||
| 3 | G, H, I, J, M... (A, B) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 4 | R (B) | (2-{[3-(4-{2-[(3-{[3-(carboxymethyl)-5-methyl-1-benzofuran-2-yl]ethynyl}benzene-1-carbonyl)amino]ethyl}piperazine-1-carbonyl)phenyl]ethynyl}-5-methyl-1-benzofuran-3-yl)acetic acid | non-polymer | 761.8 | 1 | Chemie (R2A) | |||
| 5 | S, T (A, B) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A, B: 50 - 211 (UniProt: F2WR39)
| PDB | External Database | Details |
|---|---|---|
| Gly 48 | - | expression tag |
| Ser 49 | - | expression tag |
| Glu 53 | Gln 53 | engineered mutation |
| Ser 56 | Cys 56 | engineered mutation |
| Glu 131 | Trp 131 | engineered mutation |
| Lys 185 | Phe 185 | engineered mutation |
| Glu 209 | Gln 209 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35744.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2387.8 | |
| All* | Total formula weight | 38132.4 |
