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6VLH

HIV Integrase Core domain (IN) in complex with dimer-spanning ligand

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Integrasepolymer16417872.32UniProt (F2WR39)
Pfam (PF00665)
Human immunodeficiency virus 1 (HIV-1)
2C, D, E, F, K...
(A, B)
IODIDE IONnon-polymer126.96Chemie (IOD)
3G, H, I, J, M...
(A, B)
SULFATE IONnon-polymer96.19Chemie (SO4)
4R
(B)
(2-{[3-(4-{2-[(3-{[3-(carboxymethyl)-5-methyl-1-benzofuran-2-yl]ethynyl}benzene-1-carbonyl)amino]ethyl}piperazine-1-carbonyl)phenyl]ethynyl}-5-methyl-1-benzofuran-3-yl)acetic acidnon-polymer761.81Chemie (R2A)
5S, T
(A, B)
waterwater18.054Chemie (HOH)
Sequence modifications
A, B: 50 - 211 (UniProt: F2WR39)
PDBExternal DatabaseDetails
Gly 48-expression tag
Ser 49-expression tag
Glu 53Gln 53engineered mutation
Ser 56Cys 56engineered mutation
Glu 131Trp 131engineered mutation
Lys 185Phe 185engineered mutation
Glu 209Gln 209engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight35744.6
Non-Polymers*Number of molecules16
Total formula weight2387.8
All*Total formula weight38132.4
*Water molecules are not included.

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PDB entries from 2024-11-13

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