6VKT
Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of erythromycin drug recognition
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Efflux pump membrane transporter | polymer | 1046 | 111644.0 | 3 | UniProt (A0A4T9VBR9) Pfam (PF00873) UniProt (by SIFTS) (Q5F725) | Neisseria gonorrhoeae | |
| 2 | AA, D, E, F, G... (C, A, B) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 23 | Chemie (PTY) | |||
| 3 | J (B) | ERYTHROMYCIN A | non-polymer | 733.9 | 1 | Chemie (ERY) |
Sequence modifications
A, B, C: 1 - 1046 (UniProt: A0A4T9VBR9)
| PDB | External Database | Details |
|---|---|---|
| Val 738 | Ile 738 | conflict |
| Gly 774 | Glu 774 | conflict |
| Ser 791 | Lys 791 | conflict |
| Ile 794 | Val 794 | conflict |
| Ser 800 | Thr 800 | conflict |
| Gln 807 | Glu 807 | conflict |
| Met 808 | Asn 808 | conflict |
| Ala 821 | Ser 821 | conflict |
| Glu 823 | Lys 823 | conflict |
| Gly 826 | Ala 826 | conflict |
| Glu 839 | Ala 839 | conflict |
| Ser 850 | Gly 850 | conflict |
| Leu 854 | Phe 854 | conflict |
| Ile 871 | Leu 871 | conflict |
| Ala 872 | Ile 872 | conflict |
| Ala 875 | Gly 875 | conflict |
| Ala 878 | Val 878 | conflict |
| Val 879 | Ala 879 | conflict |
| Leu 899 | Ile 899 | conflict |
| Met 902 | Ile 902 | conflict |
| Ala 907 | Ile 907 | conflict |
| Gly 1000 | Ala 1000 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 334931.9 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 17616.8 | |
| All* | Total formula weight | 352548.7 |
