6VKT
Cryo-electron microscopy structures of a gonococcal multidrug efflux pump illuminate a mechanism of erythromycin drug recognition
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Efflux pump membrane transporter | polymer | 1046 | 111644.0 | 3 | UniProt (A0A4T9VBR9) Pfam (PF00873) UniProt (by SIFTS) (Q5F725) | Neisseria gonorrhoeae | |
| 2 | AA, D, E, F, G... (C, A, B) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 23 | Chemie (PTY) PubChem (446872) PubChem (3330137) | |||
| 3 | J (B) | ERYTHROMYCIN A | non-polymer | 733.9 | 1 | Chemie (ERY) PubChem (16219331) PubChem (16757675) PubChem (22489166) PubChem (22836457) PubChem (22836628) PubChem (23229191) PubChem (24797108) PubChem (12560) PubChem (16219337) PubChem (16401342) PubChem (16759276) PubChem (18397931) PubChem (44451949) PubChem (18528813) PubChem (21550772) PubChem (22836626) PubChem (45107170) PubChem (45107190) PubChem (45107269) PubChem (45107273) PubChem (49867933) PubChem (51066560) PubChem (53384904) PubChem (53384913) PubChem (57358551) PubChem (44317775) PubChem (57587180) PubChem (44547821) PubChem (44563509) PubChem (45107581) PubChem (59974395) PubChem (60044171) PubChem (60086513) PubChem (66577477) PubChem (71024089) PubChem (50987679) PubChem (53393685) PubChem (54359201) PubChem (57357418) PubChem (57893297) PubChem (58594795) PubChem (58593559) PubChem (59022390) PubChem (59062422) PubChem (59064284) PubChem (59093569) PubChem (59284311) PubChem (59511080) PubChem (59897430) PubChem (59903654) PubChem (60009793) PubChem (60024420) PubChem (66639443) PubChem (66899541) PubChem (177390461) PubChem (177679009) PubChem (89970519) PubChem (3255) PubChem (8233) PubChem (9361) PubChem (90472408) PubChem (154401) PubChem (70897564) PubChem (71306958) PubChem (73265320) PubChem (73456721) PubChem (73946784) PubChem (456593) PubChem (467795) PubChem (489009) PubChem (86820632) PubChem (90473776) PubChem (90746906) PubChem (91434318) PubChem (91558259) PubChem (97293608) PubChem (99719271) PubChem (110189186) PubChem (6540620) PubChem (6602506) PubChem (6604221) PubChem (124226124) PubChem (124518166) PubChem (124604978) PubChem (124605145) PubChem (124605175) PubChem (124723146) PubChem (124798369) PubChem (124762348) PubChem (124822557) PubChem (9833120) PubChem (10032882) PubChem (6364614) PubChem (129009922) PubChem (129125718) PubChem (129445574) PubChem (129445576) PubChem (129666958) PubChem (10897911) PubChem (132274086) PubChem (97293607) PubChem (6604684) PubChem (6713919) PubChem (133126690) PubChem (133126790) PubChem (133550114) PubChem (133688268) PubChem (134081643) PubChem (134081274) PubChem (99719272) PubChem (134693955) PubChem (118725304) PubChem (11970254) PubChem (10034134) PubChem (12358519) PubChem (12358515) PubChem (12358508) PubChem (137705094) PubChem (124226125) PubChem (139247122) PubChem (124523502) PubChem (141945645) PubChem (124604979) PubChem (124605144) PubChem (124605146) PubChem (124716782) PubChem (124716783) PubChem (124723147) PubChem (124762349) PubChem (12358509) PubChem (12358517) PubChem (12966969) PubChem (15986867) PubChem (124822555) PubChem (124822558) PubChem (124870987) PubChem (146158524) PubChem (157254288) PubChem (163003493) PubChem (163003495) PubChem (165844830) PubChem (169440260) PubChem (126969058) PubChem (129010384) PubChem (172897573) PubChem (129119817) PubChem (129445575) PubChem (129627840) PubChem (129628729) PubChem (131665174) PubChem (133562871) PubChem (133602826) PubChem (134081264) PubChem (134693174) PubChem (135026875) PubChem (138113460) PubChem (138403276) PubChem (140886742) PubChem (141646830) PubChem (145774355) PubChem (155899868) PubChem (155900413) PubChem (161123720) PubChem (163003494) PubChem (163003496) PubChem (166604455) PubChem (166639762) PubChem (169289157) PubChem (171114703) PubChem (172897571) PubChem (16212992) PubChem (16213052) |
Sequence modifications
A, B, C: 1 - 1046 (UniProt: A0A4T9VBR9)
| PDB | External Database | Details |
|---|---|---|
| Val 738 | Ile 738 | conflict |
| Gly 774 | Glu 774 | conflict |
| Ser 791 | Lys 791 | conflict |
| Ile 794 | Val 794 | conflict |
| Ser 800 | Thr 800 | conflict |
| Gln 807 | Glu 807 | conflict |
| Met 808 | Asn 808 | conflict |
| Ala 821 | Ser 821 | conflict |
| Glu 823 | Lys 823 | conflict |
| Gly 826 | Ala 826 | conflict |
| Glu 839 | Ala 839 | conflict |
| Ser 850 | Gly 850 | conflict |
| Leu 854 | Phe 854 | conflict |
| Ile 871 | Leu 871 | conflict |
| Ala 872 | Ile 872 | conflict |
| Ala 875 | Gly 875 | conflict |
| Ala 878 | Val 878 | conflict |
| Val 879 | Ala 879 | conflict |
| Leu 899 | Ile 899 | conflict |
| Met 902 | Ile 902 | conflict |
| Ala 907 | Ile 907 | conflict |
| Gly 1000 | Ala 1000 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 334931.9 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 17616.8 | |
| All* | Total formula weight | 352548.7 |
