6VIF
Human LRH-1 ligand-binding domain bound to agonist cpd 15 and fragment of coregulator TIF-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor subfamily 5 group A member 2 | polymer | 245 | 28330.7 | 1 | UniProt (O00482) Pfam (PF00104) | Homo sapiens (Human) | Alpha-1-fetoprotein transcription factor,B1-binding factor,hB1F,CYP7A promoter-binding factor,Hepatocytic transcription factor,Liver receptor homolog 1,LRH-1 |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 14 | 1708.9 | 1 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | N-[(8beta,11alpha,12alpha)-8-{[methyl(phenyl)amino]methyl}-1,6:7,14-dicycloprosta-1(6),2,4,7(14)-tetraen-11-yl]sulfuric diamide | non-polymer | 481.7 | 1 | Chemie (QY4) | |||
| 4 | D (A) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 299 - 541 (UniProt: O00482)
| PDB | External Database | Details |
|---|---|---|
| Ser 297 | - | expression tag |
| Asn 298 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30039.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 481.7 | |
| All* | Total formula weight | 30521.3 |
