6VIE

Structure of caspase-1 in complex with gasdermin D

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Caspase-1 subunit p20	polymer	198	21561.8	1	UniProt (P29466) Pfam (PF00656)	Homo sapiens (Human)	CASP-1,Interleukin-1 beta convertase,IL-1BC,Interleukin-1 beta-converting enzyme,IL-1 beta-converting enzyme,p45
2	B (B)	Caspase-1 subunit p10	polymer	90	10402.9	1	UniProt (P29466) Pfam (PF00656)	Homo sapiens (Human)	CASP-1,Interleukin-1 beta convertase,IL-1BC,Interleukin-1 beta-converting enzyme,IL-1 beta-converting enzyme,p45
3	C, D (C, D)	Gasdermin-D	polymer	464	50818.7	2	UniProt (Q9D8T2) Pfam (PF04598) Pfam (PF17708)	Mus musculus (Mouse)	Gasdermin domain-containing protein 1

Sequence modifications

A: 120 - 303 (UniProt: P29466)

PDB	External Database	Details
Met 119	-	initiating methionine
Ala 285	Cys 285	engineered mutation

A: 304 - 316 (PDB: 6VIE)
B: 317 - 404 (UniProt: P29466)

PDB	External Database	Details
Gly 315	-	expression tag
Ser 316	-	expression tag

C, D: 1 - 487 (UniProt: Q9D8T2)

PDB	External Database	Details
Ser 0	-	expression tag
-	Arg 248	deletion
-	Lys 249	deletion
-	Ala 250	deletion
-	Val 251	deletion
-	Gly 252	deletion
-	Gln 253	deletion
-	Arg 254	deletion
-	His 255	deletion
-	His 256	deletion
-	Gly 257	deletion
-	Leu 258	deletion
-	Asn 259	deletion
-	Val 260	deletion
-	Leu 261	deletion
-	Ala 262	deletion
-	Ala 263	deletion
-	Leu 264	deletion
-	Cys 265	deletion
-	Ser 266	deletion
-	Ile 267	deletion
-	Gly 268	deletion
-	Lys 269	deletion
-	Gln 270	deletion
-	Leu 271	deletion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	133602.2
All*	Total formula weight	133602.2

*Water molecules are not included.