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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6VIE

Structure of caspase-1 in complex with gasdermin D

Functional Information from GO Data
ChainGOidnamespacecontents
A0004197molecular_functioncysteine-type endopeptidase activity
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0006508biological_processproteolysis
B0008234molecular_functioncysteine-type peptidase activity
C0001778biological_processplasma membrane repair
C0001786molecular_functionphosphatidylserine binding
C0002376biological_processimmune system process
C0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006351biological_processDNA-templated transcription
C0006954biological_processinflammatory response
C0008289molecular_functionlipid binding
C0009306biological_processprotein secretion
C0012501biological_processprogrammed cell death
C0016020cellular_componentmembrane
C0022829molecular_functionwide pore channel activity
C0031966cellular_componentmitochondrial membrane
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032732biological_processpositive regulation of interleukin-1 production
C0032741biological_processpositive regulation of interleukin-18 production
C0035655biological_processinterleukin-18-mediated signaling pathway
C0042742biological_processdefense response to bacterium
C0044546biological_processNLRP3 inflammasome complex assembly
C0045087biological_processinnate immune response
C0046513biological_processceramide biosynthetic process
C0046931biological_processpore complex assembly
C0050729biological_processpositive regulation of inflammatory response
C0050829biological_processdefense response to Gram-negative bacterium
C0050830biological_processdefense response to Gram-positive bacterium
C0051260biological_processprotein homooligomerization
C0051604biological_processprotein maturation
C0055085biological_processtransmembrane transport
C0061702cellular_componentcanonical inflammasome complex
C0070269biological_processpyroptotic inflammatory response
C0070273molecular_functionphosphatidylinositol-4-phosphate binding
C0070300molecular_functionphosphatidic acid binding
C0070498biological_processinterleukin-1-mediated signaling pathway
C0072559cellular_componentNLRP3 inflammasome complex
C0141201biological_processpyroptotic cell death
C1901612molecular_functioncardiolipin binding
D0001778biological_processplasma membrane repair
D0001786molecular_functionphosphatidylserine binding
D0002376biological_processimmune system process
D0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006351biological_processDNA-templated transcription
D0006954biological_processinflammatory response
D0008289molecular_functionlipid binding
D0009306biological_processprotein secretion
D0012501biological_processprogrammed cell death
D0016020cellular_componentmembrane
D0022829molecular_functionwide pore channel activity
D0031966cellular_componentmitochondrial membrane
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032732biological_processpositive regulation of interleukin-1 production
D0032741biological_processpositive regulation of interleukin-18 production
D0035655biological_processinterleukin-18-mediated signaling pathway
D0042742biological_processdefense response to bacterium
D0044546biological_processNLRP3 inflammasome complex assembly
D0045087biological_processinnate immune response
D0046513biological_processceramide biosynthetic process
D0046931biological_processpore complex assembly
D0050729biological_processpositive regulation of inflammatory response
D0050829biological_processdefense response to Gram-negative bacterium
D0050830biological_processdefense response to Gram-positive bacterium
D0051260biological_processprotein homooligomerization
D0051604biological_processprotein maturation
D0055085biological_processtransmembrane transport
D0061702cellular_componentcanonical inflammasome complex
D0070269biological_processpyroptotic inflammatory response
D0070273molecular_functionphosphatidylinositol-4-phosphate binding
D0070300molecular_functionphosphatidic acid binding
D0070498biological_processinterleukin-1-mediated signaling pathway
D0072559cellular_componentNLRP3 inflammasome complex
D0141201biological_processpyroptotic cell death
D1901612molecular_functioncardiolipin binding
Functional Information from PROSITE/UniProt
site_idPS00455
Number of Residues12
DetailsAMP_BINDING Putative AMP-binding domain signature. MPTSSGSEGnVK
ChainResidueDetails
AMET123-LYS134
site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HktsdStfLvFMSHG
ChainResidueDetails
AHIS224-GLY238
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"evidences":[{"source":"PubMed","id":"1574116","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {"evidences":[{"source":"PubMed","id":"1574116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32051255","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30065070","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsSite: {"description":"Cleavage; by CASP3 or CASP7","evidences":[{"source":"PubMed","id":"37327784","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsSite: {"description":"Cleavage; by caspases CASP1, CASP4/CASP11 and CASP8","evidences":[{"source":"PubMed","id":"26375259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30361383","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32553275","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38538834","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30135078","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsSite: {"description":"Cleavage; by papain","evidences":[{"source":"PubMed","id":"35794369","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P57764","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues10
DetailsModified residue: {"description":"S-(2-succinyl)cysteine","evidences":[{"source":"PubMed","id":"32820063","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues1
DetailsM-CSA 718
ChainResidueDetails
BGLU390electrostatic stabiliser
AGLY238electrostatic stabiliser
AALA285nucleofuge, nucleophile, proton acceptor, proton donor
AARG286electrostatic stabiliser

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PDB entries from 2026-02-25

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