6VI4
Nanobody-Enabled Monitoring of Kappa Opioid Receptor States
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Kappa opioid receptor | polymer | 307 | 34815.4 | 2 | UniProt (P41145) Pfam (PF00001) In PDB | Homo sapiens (Human) | KOR-1 |
| 2 | C, D | Nanobody 6 | polymer | 133 | 14730.3 | 2 | Lama glama | ||
| 3 | A, B | (3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | non-polymer | 465.6 | 2 | Chemie (JDC) | |||
| 4 | B | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
A, B: 54 - 358 (UniProt: P41145)
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| Leu 135 | Ile 135 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99091.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1317.9 | |
| All* | Total formula weight | 100409.2 |
