6VGE
Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), in complex with 16mer DNA CAGAGGATGTGGCTTC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transcriptional regulator ERG | polymer | 128 | 14927.8 | 1 | UniProt (P11308) Pfam (PF00178) | Homo sapiens (Human) | Transforming protein ERG |
| 2 | B (B) | DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') | polymer | 16 | 4954.2 | 1 | Homo sapiens | ||
| 3 | C (C) | DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3') | polymer | 16 | 4843.2 | 1 | Homo sapiens | ||
| 4 | D (D) | Runt-related transcription factor 2 | polymer | 177 | 19542.1 | 1 | UniProt (Q13950) Pfam (PF00853) | Homo sapiens (Human) | Acute myeloid leukemia 3 protein,Core-binding factor subunit alpha-1,CBF-alpha-1,Oncogene AML-3,Osteoblast-specific transcription factor 2,OSF-2,Polyomavirus enhancer-binding protein 2 alpha A subunit,PEBP2-alpha A,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core-binding factor alpha A subunit |
| 5 | E (G) | Core-binding factor subunit beta | polymer | 156 | 18263.4 | 1 | UniProt (Q13951) Pfam (PF02312) | Homo sapiens (Human) | CBF-beta,Polyomavirus enhancer-binding protein 2 beta subunit,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit |
Sequence modifications
A: 306 - 419 (UniProt: P11308)
G: 1 - 142 (UniProt: Q13951)
| PDB | External Database | Details |
|---|---|---|
| Gly 302 | - | expression tag |
| Pro 303 | - | expression tag |
| His 304 | - | expression tag |
| Met 305 | - | expression tag |
| Ser 420 | - | expression tag |
| Tyr 421 | - | expression tag |
| His 422 | - | expression tag |
| Ala 423 | - | expression tag |
| His 424 | - | expression tag |
| Pro 425 | - | expression tag |
| Gln 426 | - | expression tag |
| Lys 427 | - | expression tag |
| Met 428 | - | expression tag |
| Asn 429 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 62530.7 | |
| All* | Total formula weight | 62530.7 |
