6VG8
Crystal structure of the DNA binding domains of human FLI1 and Runx2 in complex with 16-mer DNA CAGAGGATGTGGCTTC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Friend leukemia integration 1 transcription factor | polymer | 104 | 12098.7 | 1 | UniProt (Q01543) Pfam (PF00178) In PDB | Homo sapiens (Human) | Proto-oncogene Fli-1,Transcription factor ERGB |
| 2 | B | DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') | polymer | 16 | 4954.2 | 1 | Homo sapiens | ||
| 3 | C | DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3') | polymer | 16 | 4843.2 | 1 | Homo sapiens | ||
| 4 | D | Runt-related transcription factor 2 | polymer | 123 | 13701.7 | 1 | UniProt (Q13950) Pfam (PF00853) In PDB | Homo sapiens (Human) | Acute myeloid leukemia 3 protein,Core-binding factor subunit alpha-1,CBF-alpha-1,Oncogene AML-3,Osteoblast-specific transcription factor 2,OSF-2,Polyomavirus enhancer-binding protein 2 alpha A subunit,PEBP2-alpha A,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core-binding factor alpha A subunit |
Sequence modifications
A: 276 - 375 (UniProt: Q01543)
| PDB | External Database | Details |
|---|---|---|
| Gly 272 | - | expression tag |
| Pro 273 | - | expression tag |
| His 274 | - | expression tag |
| Met 275 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 35597.7 | |
| All* | Total formula weight | 35597.7 |
