6VEQ
Con-Ins G1 in complex with the human insulin microreceptor in turn in complex with Fv 83-7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, L (A, G) | Con-Ins G1a A chain | polymer | 20 | 2358.7 | 2 | UniProt (A0A0B5AC95) | Conus geographus | |
| 2 | B, K (B, H) | Con-Ins G1 B chain | polymer | 23 | 2802.1 | 2 | UniProt (A0A0B5A8Q2) | Conus geographus | |
| 3 | C, G (E, K) | Insulin receptor subunit alpha | polymer | 317 | 36231.8 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (Human) | IR |
| 4 | D, H (F, L) | Insulin receptor | polymer | 16 | 1922.1 | 2 | UniProt (P06213) | Homo sapiens | IR |
| 5 | E, I (C, I) | Fv 83-7 heavy chain | polymer | 138 | 15058.7 | 2 | Mus musculus (Mouse) | ||
| 6 | F, J (D, J) | Fv 83-7 light chain | polymer | 121 | 13367.9 | 2 | Mus musculus (Mouse) | ||
| 7 | M, O (M, O) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 8 | N, P (N, P) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G32152BH) | |||
| 9 | Q, R, S, W, X... (E, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 10 | T, U, V, Z (E, D, K) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) |
Sequence modifications
E, K: 1 - 310 (UniProt: P06213)
F, L: 704 - 719 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | conflict |
| Ser 311 | - | expression tag |
| Ser 312 | - | expression tag |
| Ser 313 | - | expression tag |
| Leu 314 | - | expression tag |
| Val 315 | - | expression tag |
| Pro 316 | - | expression tag |
| Arg 317 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro 718 | Lys 745 | conflict |
| Ser 719 | Thr 746 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 143482.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2962.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1711.5 | |
| All* | Total formula weight | 148157.0 |
