6VEQ

Con-Ins G1 in complex with the human insulin microreceptor in turn in complex with Fv 83-7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, G	Con-Ins G1a A chain	polymer	20	2358.7	2	UniProt (A0A0B5AC95) In PDB	Conus geographus
2	B, H	Con-Ins G1 B chain	polymer	23	2802.1	2	UniProt (A0A0B5A8Q2) In PDB	Conus geographus
3	E, K	Insulin receptor subunit alpha	polymer	317	36231.8	2	UniProt (P06213) Pfam (PF01030) Pfam (PF00757) In PDB	Homo sapiens (Human)	IR
4	F, L	Insulin receptor	polymer	16	1922.1	2	UniProt (P06213) In PDB	Homo sapiens	IR
5	C, I	Fv 83-7 heavy chain	polymer	138	15058.7	2		Mus musculus (Mouse)
6	D, J	Fv 83-7 light chain	polymer	121	13367.9	2		Mus musculus (Mouse)
7	M, O	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G81315DD)
8	N, P	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	2	In PDB GlyTouCan (G32152BH)
9	E, K	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
10	E, D, K	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)

Sequence modifications

E, K: 1 - 310 (UniProt: P06213)

PDB	External Database	Details
His 144	Tyr 171	conflict
Ser 311	-	expression tag
Ser 312	-	expression tag
Ser 313	-	expression tag
Leu 314	-	expression tag
Val 315	-	expression tag
Pro 316	-	expression tag
Arg 317	-	expression tag

F, L: 704 - 719 (UniProt: P06213)

PDB	External Database	Details
Pro 718	Lys 745	conflict
Ser 719	Thr 746	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	143482.7
Branched	Number of molecules	4
	Total formula weight	2962.7
Non-Polymers*	Number of molecules	10
	Total formula weight	1711.5
All*	Total formula weight	148157.0

*Water molecules are not included.