6V9I

cryo-EM structure of Cullin5 bound to RING-box protein 2 (Cul5-Rbx2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Immunoglobulin G-binding protein G,Cullin-5	polymer	863	100456.5	1	UniProt (P06654) UniProt (Q93034) Pfam (PF01378) Pfam (PF00888) Pfam (PF10557)	Streptococcus sp. group G	IgG-binding protein G,CUL-5,Vasopressin-activated calcium-mobilizing receptor 1,VACM-1
2	B (R)	RING-box protein 2	polymer	113	12721.5	1	UniProt (Q9WTZ1) Pfam (PF12678)	Mus musculus (Mouse)	Rbx2,RING finger protein 7,Sensitive to apoptosis gene protein
3	C, D, E (R)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)

Sequence modifications

C: -66 - -13 (UniProt: P06654)

PDB	External Database	Details
Met -82	-	expression tag
Gly -81	-	expression tag
Ser -80	-	expression tag
Ser -79	-	expression tag
His -78	-	expression tag
His -77	-	expression tag
His -76	-	expression tag
His -75	-	expression tag
His -74	-	expression tag
His -73	-	expression tag
Ser -72	-	expression tag
Gln -71	-	expression tag
Asp -70	-	expression tag
Pro -69	-	expression tag
Met -68	-	expression tag
Glu -67	-	expression tag
Ile -12	-	linker
Pro -11	-	linker
Thr -10	-	linker
Thr -9	-	linker
Glu -8	-	linker
Asn -7	-	linker
Leu -6	-	linker
Tyr -5	-	linker
Phe -4	-	linker
Gln -3	-	linker
Gly -2	-	linker
Glu -1	-	linker
Phe 0	-	linker
Met 1	-	linker

C: 2 - 780 (UniProt: Q93034)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	113178.0
Non-Polymers*	Number of molecules	3
	Total formula weight	196.2
All*	Total formula weight	113374.2

*Water molecules are not included.