6V9I

cryo-EM structure of Cullin5 bound to RING-box protein 2 (Cul5-Rbx2)

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005618	cellular_component	cell wall
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0016567	biological_process	protein ubiquitination
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0038023	molecular_function	signaling receptor activity
C	0038128	biological_process	ERBB2 signaling pathway
C	0070588	biological_process	calcium ion transmembrane transport
C	0090734	cellular_component	site of DNA damage
C	0097193	biological_process	intrinsic apoptotic signaling pathway
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0008270	molecular_function	zinc ion binding
R	0008631	biological_process	intrinsic apoptotic signaling pathway in response to oxidative stress
R	0008637	biological_process	apoptotic mitochondrial changes
R	0016567	biological_process	protein ubiquitination
R	0021799	biological_process	cerebral cortex radially oriented cell migration
R	0021942	biological_process	radial glia guided migration of Purkinje cell
R	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
R	0043066	biological_process	negative regulation of apoptotic process
R	0045116	biological_process	protein neddylation
R	0046872	molecular_function	metal ion binding
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0061663	molecular_function	NEDD8 ligase activity
R	0097602	molecular_function	cullin family protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN R 201

Chain	Residue
R	CYS50
R	CYS53
R	HIS85
R	CYS88

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site_id	AC2
Number of Residues	3
Details	binding site for residue ZN R 202

Chain	Residue
R	CYS80
R	HIS82
R	CYS99

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN R 203

Chain	Residue
R	CYS73
R	CYS87
R	CYS61
R	CYS64

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Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKeqIewLIEHkYIrRdesdintFiYmA

Chain	Residue	Details
C	ILE753-ALA780

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
R	CYS61-GLN103

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
R	CYS50
R	CYS88
R	CYS99
R	CYS102
R	CYS53
R	CYS61
R	CYS64
R	CYS73
R	CYS80
R	HIS82
R	HIS85
R	CYS87

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q9UBF6

Chain	Residue	Details
R	ALA2

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