6V9C

Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fibroblast growth factor receptor 4	polymer	300	33867.2	1	UniProt (P22455) Pfam (PF07714) In PDB	Homo sapiens (Human)	FGFR-4
2	A	N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide	non-polymer		520.4	1	Chemie (QS7)
3	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4		water	water		18.0	165	Chemie (HOH)

Sequence modifications

A: 450 - 751 (UniProt: P22455)

PDB	External Database	Details
Met 449	-	initiating methionine
-	Pro 570	deletion
-	Asp 571	deletion
-	Leu 572	deletion
-	Ser 573	deletion
-	Pro 574	deletion
-	Asp 575	deletion
-	Gly 576	deletion
-	Pro 577	deletion
-	Arg 578	deletion
His 752	-	expression tag
His 753	-	expression tag
His 754	-	expression tag
His 755	-	expression tag
His 756	-	expression tag
His 757	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33867.2
Non-Polymers*	Number of molecules	3
	Total formula weight	712.5
All*	Total formula weight	34579.7

*Water molecules are not included.