6V9C
Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 4 | polymer | 300 | 33867.2 | 1 | UniProt (P22455) Pfam (PF07714) | Homo sapiens (Human) | FGFR-4 |
| 2 | B (A) | N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide | non-polymer | 520.4 | 1 | Chemie (QS7) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (A) | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A: 450 - 751 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Met 449 | - | initiating methionine |
| - | Pro 570 | deletion |
| - | Asp 571 | deletion |
| - | Leu 572 | deletion |
| - | Ser 573 | deletion |
| - | Pro 574 | deletion |
| - | Asp 575 | deletion |
| - | Gly 576 | deletion |
| - | Pro 577 | deletion |
| - | Arg 578 | deletion |
| His 752 | - | expression tag |
| His 753 | - | expression tag |
| His 754 | - | expression tag |
| His 755 | - | expression tag |
| His 756 | - | expression tag |
| His 757 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33867.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 712.5 | |
| All* | Total formula weight | 34579.7 |
