6V8X

VRC01 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I	Envelope glycoprotein gp120	polymer	471	52791.8	3	UniProt (Q2N0S6) Pfam (PF00516) In PDB	Human immunodeficiency virus 1 (HIV-1)	Env polyprotein
2	B, F, J	Envelope glycoprotein gp41	polymer	145	16447.7	3	UniProt (Q2N0S9) Pfam (PF00517) In PDB	Human immunodeficiency virus 1 (HIV-1)	Env polyprotein
3	C, G, K	VRC01 Fab Heavy Chain	polymer	224	24367.6	3	UniProt (Q6N095) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	D, H, L	VRC01 Fab Light Chain	polymer	208	22930.4	3	UniProt (Q6PIL8) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
5	k, M, Y	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	3	In PDB GlyTouCan (G81315DD)
6	d, e, g, h, i...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	21	In PDB GlyTouCan (G42666HT)
7	a, b, c, f, m...	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	12	In PDB GlyTouCan (G15407YE)
8	B, E, F, I, J...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	15	Chemie (NAG)

Sequence modifications

A, E, I: 33 - 505 (UniProt: Q2N0S6)

B, F, J: 520 - 664 (UniProt: Q2N0S9)

PDB	External Database	Details
Cys 605	Thr 604	conflict

C, G, K: 1 - 114 (PDB: 6V8X)
C, G, K: 115 - 216 (UniProt: Q6N095)

PDB	External Database	Details
Ala 211	Val 243	conflict

D, H, L: 3 - 106 (PDB: 6V8X)
D, H, L: 107 - 216 (UniProt: Q6PIL8)

PDB	External Database	Details
Arg 204	Ser 224	conflict

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.