6V7N
Crystal Structure of a human Lysosome Resident Glycoprotein, Lysosomal Acid Lipase, and its Implications in Cholesteryl Ester Storage Disease (CESD)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lysosomal acid lipase/cholesteryl ester hydrolase | polymer | 384 | 43719.5 | 2 | UniProt (P38571) Pfam (PF00561) | Homo sapiens (Human) | LAL,Cholesteryl esterase,Lipase A,Sterol esterase |
| 2 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | E, G, H (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 4 | F, I, J (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 378 (UniProt: P38571)
| PDB | External Database | Details |
|---|---|---|
| Gln 51 | Asn 72 | engineered mutation |
| Gln 80 | Asn 101 | engineered mutation |
| Gln 300 | Asn 321 | engineered mutation |
| Ala 379 | - | expression tag |
| Ser 380 | - | expression tag |
| Glu 381 | - | expression tag |
| Asn 382 | - | expression tag |
| Asn 383 | - | expression tag |
| Leu 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87439.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 951.8 | |
| All* | Total formula weight | 89239.7 |
