6V63

SETD3 WT in Complex with an Actin Peptide with His73 Replaced with Glutamine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (Y, Z)	Actin, cytoplasmic 1	polymer	23	2858.2	2	UniProt (C9JUM1) UniProt (by SIFTS) (P63261)	Homo sapiens
2	B, D (A, B)	Actin-histidine N-methyltransferase	polymer	596	67486.2	2	UniProt (Q86TU7) Pfam (PF00856) Pfam (PF09273)	Homo sapiens (Human)	SET domain-containing protein 3,hSETD3
3	E, G (Y, A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL) PubChem (753)
4	DA, F (B, A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
5	AA, BA, CA, EA, FA... (A, Z, B)	1,2-ETHANEDIOL	non-polymer		62.1	36	Chemie (EDO)
6	Z (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT) PubChem (175)
7	TA, UA, VA, WA (Y, A, Z, B)	water	water		18.0	667	Chemie (HOH)

Sequence modifications

Y, Z: 66 - 88 (UniProt: C9JUM1)

PDB	External Database	Details
Gln 73	His 73	engineered mutation

A, B: 0 - 593 (UniProt: Q86TU7)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	140688.8
Non-Polymers*	Number of molecules	41
	Total formula weight	3246.5
All*	Total formula weight	143935.3

*Water molecules are not included.