6V22
Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, B, C, D) | Calcium-activated potassium channel subunit alpha-1 | polymer | 1065 | 119988.1 | 4 | UniProt (Q12791) Pfam (PF00520) Pfam (PF07885) Pfam (PF22614) Pfam (PF03493) Pfam (PF21014) | Homo sapiens (Human) | BK channel,BKCA alpha,Calcium-activated potassium channel,subfamily M subunit alpha-1,K(VCA)alpha,KCa1.1,Maxi K channel,MaxiK,Slo-alpha,Slo1,Slowpoke homolog,hSlo |
| 2 | B, D, F, H (E, F, G, H) | Calcium-activated potassium channel subunit beta-4 | polymer | 219 | 24991.8 | 4 | UniProt (Q86W47) Pfam (PF03185) | Homo sapiens (Human) | BK channel subunit beta-4,Hbeta4,Calcium-activated potassium channel,subfamily M subunit beta-4,Charybdotoxin receptor subunit beta-4,K(VCA)beta-4,Maxi K channel subunit beta-4,Slo-beta-4 |
| 3 | I, LC, NB, PA (A, D, C, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | J, K, MC, NC, OB... (A, D, C, B) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 5 | AA, AC, AD, BA, BC... (A, G, H, F, E...) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 60 | Chemie (POV) | |||
| 6 | AB, BB, R, S, T... (B, A, D, C) | CHOLESTEROL | non-polymer | 386.7 | 16 | Chemie (CLR) | |||
| 7 | V, W, X, Y (A) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 8 | CD, DD, EC, FC, GB... (H, G, F, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 1 - 1056 (UniProt: Q12791)
E, F, G, H: 2001 - 2210 (UniProt: Q86W47)
| PDB | External Database | Details |
|---|---|---|
| Ser 1057 | - | expression tag |
| Asn 1058 | - | expression tag |
| Ser 1059 | - | expression tag |
| Leu 1060 | - | expression tag |
| Glu 1061 | - | expression tag |
| Val 1062 | - | expression tag |
| Leu 1063 | - | expression tag |
| Phe 1064 | - | expression tag |
| Gln 1065 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 2211 | - | expression tag |
| Asn 2212 | - | expression tag |
| Ser 2213 | - | expression tag |
| Leu 2214 | - | expression tag |
| Glu 2215 | - | expression tag |
| Val 2216 | - | expression tag |
| Leu 2217 | - | expression tag |
| Phe 2218 | - | expression tag |
| Gln 2219 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 579919.3 | |
| Non-Polymers* | Number of molecules | 100 |
| Total formula weight | 54134.9 | |
| All* | Total formula weight | 634054.2 |
