6V1E
Crystal structure of the bromodomain of human BRD7 bound to BI7273
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 7 | polymer | 126 | 14593.9 | 1 | UniProt (Q9NPI1) Pfam (PF00439) | Homo sapiens (Human) | 75 kDa bromodomain protein,Protein CELTIX-1 |
| 2 | B (A) | 4-[4-[(dimethylamino)methyl]-3,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one | non-polymer | 353.4 | 1 | Chemie (5SW) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A: 129 - 250 (UniProt: Q9NPI1)
| PDB | External Database | Details |
|---|---|---|
| Gly 125 | - | expression tag |
| Ala 126 | - | expression tag |
| Ala 127 | - | expression tag |
| Ser 128 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14593.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 415.5 | |
| All* | Total formula weight | 15009.3 |
