6V0P

PRMT5 complex bound to covalent PBM inhibitor BRD6711

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein arginine N-methyltransferase 5	polymer	637	72766.7	1	UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286)	Homo sapiens (Human)	72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs
2	B (B)	Methylosome protein 50	polymer	342	36723.2	1	UniProt (Q9BQA1) Pfam (PF00400)	Homo sapiens (Human)	MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50
3	C (A)	2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide	non-polymer		356.8	1	Chemie (QN4) PubChem (155804497)
4	D, E (A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL) PubChem (312)
5	F (A)	SINEFUNGIN	non-polymer		381.4	1	Chemie (SFG) PubChem (176612030) PubChem (177116271) PubChem (25246236) PubChem (46875078) PubChem (46936257) PubChem (70602121) PubChem (456189) PubChem (4065234) PubChem (65482) PubChem (70789212) PubChem (93287274) PubChem (92403972) PubChem (93287270) PubChem (93287272) PubChem (93475589) PubChem (6917665) PubChem (12771338) PubChem (12771337) PubChem (131971033) PubChem (131972810) PubChem (138626357) PubChem (156562738) PubChem (162866891) PubChem (163339130) PubChem (168280605)
6	G, H (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL) PubChem (753)
7	I, J (A, B)	water	water		18.0	637	Chemie (HOH)

Sequence modifications

B: 2 - 342 (UniProt: Q9BQA1)

PDB	External Database	Details
Pro 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	109489.8
Non-Polymers*	Number of molecules	6
	Total formula weight	993.3
All*	Total formula weight	110483.1

*Water molecules are not included.