6V0P
PRMT5 complex bound to covalent PBM inhibitor BRD6711
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein arginine N-methyltransferase 5 | polymer | 637 | 72766.7 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) In PDB | Homo sapiens (Human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
| 2 | B | Methylosome protein 50 | polymer | 342 | 36723.2 | 1 | UniProt (Q9BQA1) Pfam (PF00400) In PDB | Homo sapiens (Human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
| 3 | A | 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide | non-polymer | 356.8 | 1 | Chemie (QN4) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | A | SINEFUNGIN | non-polymer | 381.4 | 1 | Chemie (SFG) | |||
| 6 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 637 | Chemie (HOH) |
Sequence modifications
B: 2 - 342 (UniProt: Q9BQA1)
| PDB | External Database | Details |
|---|---|---|
| Pro 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 109489.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 993.3 | |
| All* | Total formula weight | 110483.1 |
