6V01
structure of human KCNQ1-KCNE3-CaM complex with PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (B, E, H, K) | Calmodulin-1 | polymer | 149 | 16852.5 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (Human) | |
| 2 | B, D, F, H (C, F, I, L) | Potassium voltage-gated channel subfamily E member 3 | polymer | 103 | 11725.4 | 4 | UniProt (Q9Y6H6) Pfam (PF02060) | Homo sapiens (Human) | MinK-related peptide 2,Minimum potassium ion channel-related peptide 2,Potassium channel subunit beta MiRP2 |
| 3 | I, J, K, L (J, A, D, G) | Potassium voltage-gated channel subfamily KQT member 1 | polymer | 557 | 63258.6 | 4 | UniProt (P51787) Pfam (PF00520) Pfam (PF03520) | Homo sapiens (Human) | IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,KQT-like 1,Voltage-gated potassium channel subunit Kv7.1 |
| 4 | M, N, O, P, Q... (B, E, H, K) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) PubChem (271) | |||
| 5 | U, V, W, X (J, A, D, G) | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 4 | Chemie (PT5) PubChem (21584053) PubChem (46891800) PubChem (24742075) PubChem (25021172) PubChem (53480261) PubChem (49867532) PubChem (53731018) PubChem (74343116) PubChem (644093) PubChem (88368868) PubChem (101127471) PubChem (5497157) PubChem (101103400) PubChem (137349554) PubChem (146672970) PubChem (162802760) PubChem (177693253) PubChem (137349667) PubChem (155387720) |
Sequence modifications
J, A, D, G: 76 - 620 (UniProt: P51787)
| PDB | External Database | Details |
|---|---|---|
| Met 75 | - | initiating methionine |
| Ser 621 | - | expression tag |
| Asn 622 | - | expression tag |
| Ser 623 | - | expression tag |
| Leu 624 | - | expression tag |
| Glu 625 | - | expression tag |
| Val 626 | - | expression tag |
| Leu 627 | - | expression tag |
| Phe 628 | - | expression tag |
| Gln 629 | - | expression tag |
| Gly 630 | - | expression tag |
| Pro 631 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 367346.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4509.0 | |
| All* | Total formula weight | 371855.0 |
