6V01

structure of human KCNQ1-KCNE3-CaM complex with PIP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, E, H, K	Calmodulin-1	polymer	149	16852.5	4	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (Human)
2	C, F, I, L	Potassium voltage-gated channel subfamily E member 3	polymer	103	11725.4	4	UniProt (Q9Y6H6) Pfam (PF02060) In PDB	Homo sapiens (Human)	MinK-related peptide 2,Minimum potassium ion channel-related peptide 2,Potassium channel subunit beta MiRP2
3	J, A, D, G	Potassium voltage-gated channel subfamily KQT member 1	polymer	557	63258.6	4	UniProt (P51787) Pfam (PF00520) Pfam (PF07885) Pfam (PF03520) In PDB	Homo sapiens (Human)	IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,KQT-like 1,Voltage-gated potassium channel subunit Kv7.1
4	B, E, H, K	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)
5	J, A, D, G	[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate	non-polymer		1047.1	4	Chemie (PT5)

Sequence modifications

J, A, D, G: 76 - 620 (UniProt: P51787)

PDB	External Database	Details
Met 75	-	initiating methionine
Ser 621	-	expression tag
Asn 622	-	expression tag
Ser 623	-	expression tag
Leu 624	-	expression tag
Glu 625	-	expression tag
Val 626	-	expression tag
Leu 627	-	expression tag
Phe 628	-	expression tag
Gln 629	-	expression tag
Gly 630	-	expression tag
Pro 631	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	367346.1
Non-Polymers*	Number of molecules	12
	Total formula weight	4509.0
All*	Total formula weight	371855.0

*Water molecules are not included.