6V01

structure of human KCNQ1-KCNE3-CaM complex with PIP2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000922	cellular_component	spindle pole
B	0002027	biological_process	regulation of heart rate
B	0005246	molecular_function	calcium channel regulator activity
B	0005509	molecular_function	calcium ion binding
B	0005513	biological_process	detection of calcium ion
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005876	cellular_component	spindle microtubule
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0010856	molecular_function	adenylate cyclase activator activity
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0016240	biological_process	autophagosome membrane docking
B	0019855	molecular_function	calcium channel inhibitor activity
B	0019901	molecular_function	protein kinase binding
B	0021762	biological_process	substantia nigra development
B	0030017	cellular_component	sarcomere
B	0030672	cellular_component	synaptic vesicle membrane
B	0031432	molecular_function	titin binding
B	0031514	cellular_component	motile cilium
B	0031982	cellular_component	vesicle
B	0032465	biological_process	regulation of cytokinesis
B	0032991	cellular_component	protein-containing complex
B	0034704	cellular_component	calcium channel complex
B	0035458	biological_process	cellular response to interferon-beta
B	0042995	cellular_component	cell projection
B	0043209	cellular_component	myelin sheath
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0044305	cellular_component	calyx of Held
B	0044325	molecular_function	transmembrane transporter binding
B	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0051592	biological_process	response to calcium ion
B	0055117	biological_process	regulation of cardiac muscle contraction
B	0060291	biological_process	long-term synaptic potentiation
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
B	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
B	0071346	biological_process	cellular response to type II interferon
B	0072542	molecular_function	protein phosphatase activator activity
B	0097225	cellular_component	sperm midpiece
B	0097720	biological_process	calcineurin-mediated signaling
B	0098901	biological_process	regulation of cardiac muscle cell action potential
B	0099523	cellular_component	presynaptic cytosol
B	0140056	biological_process	organelle localization by membrane tethering
B	0140238	biological_process	presynaptic endocytosis
B	0141110	molecular_function	transporter inhibitor activity
B	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
B	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
B	1902494	cellular_component	catalytic complex
B	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
B	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005251	molecular_function	delayed rectifier potassium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0015459	molecular_function	potassium channel regulator activity
C	0016020	cellular_component	membrane
C	0030425	cellular_component	dendrite
C	0030644	biological_process	intracellular chloride ion homeostasis
C	0031982	cellular_component	vesicle
C	0032809	cellular_component	neuronal cell body membrane
C	0042995	cellular_component	cell projection
C	0043204	cellular_component	perikaryon
C	0043266	biological_process	regulation of potassium ion transport
C	0044325	molecular_function	transmembrane transporter binding
C	0045121	cellular_component	membrane raft
C	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
C	0071805	biological_process	potassium ion transmembrane transport
C	0086005	biological_process	ventricular cardiac muscle cell action potential
C	0086011	biological_process	membrane repolarization during action potential
C	0086091	biological_process	regulation of heart rate by cardiac conduction
C	0097623	biological_process	potassium ion export across plasma membrane
C	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
C	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
C	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
C	1905025	biological_process	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
C	1990794	cellular_component	basolateral part of cell
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000922	cellular_component	spindle pole
E	0002027	biological_process	regulation of heart rate
E	0005246	molecular_function	calcium channel regulator activity
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005876	cellular_component	spindle microtubule
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0021762	biological_process	substantia nigra development
E	0030017	cellular_component	sarcomere
E	0030672	cellular_component	synaptic vesicle membrane
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031982	cellular_component	vesicle
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035458	biological_process	cellular response to interferon-beta
E	0042995	cellular_component	cell projection
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0044305	cellular_component	calyx of Held
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050848	biological_process	regulation of calcium-mediated signaling
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060291	biological_process	long-term synaptic potentiation
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0072542	molecular_function	protein phosphatase activator activity
E	0097225	cellular_component	sperm midpiece
E	0097720	biological_process	calcineurin-mediated signaling
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0099523	cellular_component	presynaptic cytosol
E	0140056	biological_process	organelle localization by membrane tethering
E	0140238	biological_process	presynaptic endocytosis
E	0141110	molecular_function	transporter inhibitor activity
E	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
E	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
E	1902494	cellular_component	catalytic complex
E	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
F	0005249	molecular_function	voltage-gated potassium channel activity
F	0005251	molecular_function	delayed rectifier potassium channel activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006813	biological_process	potassium ion transport
F	0006814	biological_process	sodium ion transport
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0015459	molecular_function	potassium channel regulator activity
F	0016020	cellular_component	membrane
F	0030425	cellular_component	dendrite
F	0030644	biological_process	intracellular chloride ion homeostasis
F	0031982	cellular_component	vesicle
F	0032809	cellular_component	neuronal cell body membrane
F	0042995	cellular_component	cell projection
F	0043204	cellular_component	perikaryon
F	0043266	biological_process	regulation of potassium ion transport
F	0044325	molecular_function	transmembrane transporter binding
F	0045121	cellular_component	membrane raft
F	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
F	0071805	biological_process	potassium ion transmembrane transport
F	0086005	biological_process	ventricular cardiac muscle cell action potential
F	0086011	biological_process	membrane repolarization during action potential
F	0086091	biological_process	regulation of heart rate by cardiac conduction
F	0097623	biological_process	potassium ion export across plasma membrane
F	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
F	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
F	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
F	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
F	1905025	biological_process	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
F	1990794	cellular_component	basolateral part of cell
G	0005216	molecular_function	monoatomic ion channel activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport
H	0000086	biological_process	G2/M transition of mitotic cell cycle
H	0000922	cellular_component	spindle pole
H	0002027	biological_process	regulation of heart rate
H	0005246	molecular_function	calcium channel regulator activity
H	0005509	molecular_function	calcium ion binding
H	0005513	biological_process	detection of calcium ion
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005876	cellular_component	spindle microtubule
H	0005886	cellular_component	plasma membrane
H	0005929	cellular_component	cilium
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0010856	molecular_function	adenylate cyclase activator activity
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016240	biological_process	autophagosome membrane docking
H	0019855	molecular_function	calcium channel inhibitor activity
H	0019901	molecular_function	protein kinase binding
H	0021762	biological_process	substantia nigra development
H	0030017	cellular_component	sarcomere
H	0030672	cellular_component	synaptic vesicle membrane
H	0031432	molecular_function	titin binding
H	0031514	cellular_component	motile cilium
H	0031982	cellular_component	vesicle
H	0032465	biological_process	regulation of cytokinesis
H	0032991	cellular_component	protein-containing complex
H	0034704	cellular_component	calcium channel complex
H	0035458	biological_process	cellular response to interferon-beta
H	0042995	cellular_component	cell projection
H	0043209	cellular_component	myelin sheath
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0044305	cellular_component	calyx of Held
H	0044325	molecular_function	transmembrane transporter binding
H	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050848	biological_process	regulation of calcium-mediated signaling
H	0051592	biological_process	response to calcium ion
H	0055117	biological_process	regulation of cardiac muscle contraction
H	0060291	biological_process	long-term synaptic potentiation
H	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
H	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
H	0071346	biological_process	cellular response to type II interferon
H	0072542	molecular_function	protein phosphatase activator activity
H	0097225	cellular_component	sperm midpiece
H	0097720	biological_process	calcineurin-mediated signaling
H	0098901	biological_process	regulation of cardiac muscle cell action potential
H	0099523	cellular_component	presynaptic cytosol
H	0140056	biological_process	organelle localization by membrane tethering
H	0140238	biological_process	presynaptic endocytosis
H	0141110	molecular_function	transporter inhibitor activity
H	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
H	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
H	1902494	cellular_component	catalytic complex
H	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
H	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
I	0005249	molecular_function	voltage-gated potassium channel activity
I	0005251	molecular_function	delayed rectifier potassium channel activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006813	biological_process	potassium ion transport
I	0006814	biological_process	sodium ion transport
I	0008076	cellular_component	voltage-gated potassium channel complex
I	0015459	molecular_function	potassium channel regulator activity
I	0016020	cellular_component	membrane
I	0030425	cellular_component	dendrite
I	0030644	biological_process	intracellular chloride ion homeostasis
I	0031982	cellular_component	vesicle
I	0032809	cellular_component	neuronal cell body membrane
I	0042995	cellular_component	cell projection
I	0043204	cellular_component	perikaryon
I	0043266	biological_process	regulation of potassium ion transport
I	0044325	molecular_function	transmembrane transporter binding
I	0045121	cellular_component	membrane raft
I	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
I	0071805	biological_process	potassium ion transmembrane transport
I	0086005	biological_process	ventricular cardiac muscle cell action potential
I	0086011	biological_process	membrane repolarization during action potential
I	0086091	biological_process	regulation of heart rate by cardiac conduction
I	0097623	biological_process	potassium ion export across plasma membrane
I	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
I	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
I	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
I	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
I	1905025	biological_process	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
I	1990794	cellular_component	basolateral part of cell
J	0005216	molecular_function	monoatomic ion channel activity
J	0005249	molecular_function	voltage-gated potassium channel activity
J	0006811	biological_process	monoatomic ion transport
J	0006813	biological_process	potassium ion transport
J	0008076	cellular_component	voltage-gated potassium channel complex
J	0016020	cellular_component	membrane
J	0055085	biological_process	transmembrane transport
K	0000086	biological_process	G2/M transition of mitotic cell cycle
K	0000922	cellular_component	spindle pole
K	0002027	biological_process	regulation of heart rate
K	0005246	molecular_function	calcium channel regulator activity
K	0005509	molecular_function	calcium ion binding
K	0005513	biological_process	detection of calcium ion
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005876	cellular_component	spindle microtubule
K	0005886	cellular_component	plasma membrane
K	0005929	cellular_component	cilium
K	0007186	biological_process	G protein-coupled receptor signaling pathway
K	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
K	0008076	cellular_component	voltage-gated potassium channel complex
K	0010856	molecular_function	adenylate cyclase activator activity
K	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K	0016020	cellular_component	membrane
K	0016240	biological_process	autophagosome membrane docking
K	0019855	molecular_function	calcium channel inhibitor activity
K	0019901	molecular_function	protein kinase binding
K	0021762	biological_process	substantia nigra development
K	0030017	cellular_component	sarcomere
K	0030672	cellular_component	synaptic vesicle membrane
K	0031432	molecular_function	titin binding
K	0031514	cellular_component	motile cilium
K	0031982	cellular_component	vesicle
K	0032465	biological_process	regulation of cytokinesis
K	0032991	cellular_component	protein-containing complex
K	0034704	cellular_component	calcium channel complex
K	0035458	biological_process	cellular response to interferon-beta
K	0042995	cellular_component	cell projection
K	0043209	cellular_component	myelin sheath
K	0043539	molecular_function	protein serine/threonine kinase activator activity
K	0044305	cellular_component	calyx of Held
K	0044325	molecular_function	transmembrane transporter binding
K	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
K	0046872	molecular_function	metal ion binding
K	0048306	molecular_function	calcium-dependent protein binding
K	0050848	biological_process	regulation of calcium-mediated signaling
K	0051592	biological_process	response to calcium ion
K	0055117	biological_process	regulation of cardiac muscle contraction
K	0060291	biological_process	long-term synaptic potentiation
K	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
K	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
K	0071346	biological_process	cellular response to type II interferon
K	0072542	molecular_function	protein phosphatase activator activity
K	0097225	cellular_component	sperm midpiece
K	0097720	biological_process	calcineurin-mediated signaling
K	0098901	biological_process	regulation of cardiac muscle cell action potential
K	0099523	cellular_component	presynaptic cytosol
K	0140056	biological_process	organelle localization by membrane tethering
K	0140238	biological_process	presynaptic endocytosis
K	0141110	molecular_function	transporter inhibitor activity
K	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
K	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
K	1902494	cellular_component	catalytic complex
K	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
K	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
L	0005249	molecular_function	voltage-gated potassium channel activity
L	0005251	molecular_function	delayed rectifier potassium channel activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005886	cellular_component	plasma membrane
L	0006811	biological_process	monoatomic ion transport
L	0006813	biological_process	potassium ion transport
L	0006814	biological_process	sodium ion transport
L	0008076	cellular_component	voltage-gated potassium channel complex
L	0015459	molecular_function	potassium channel regulator activity
L	0016020	cellular_component	membrane
L	0030425	cellular_component	dendrite
L	0030644	biological_process	intracellular chloride ion homeostasis
L	0031982	cellular_component	vesicle
L	0032809	cellular_component	neuronal cell body membrane
L	0042995	cellular_component	cell projection
L	0043204	cellular_component	perikaryon
L	0043266	biological_process	regulation of potassium ion transport
L	0044325	molecular_function	transmembrane transporter binding
L	0045121	cellular_component	membrane raft
L	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
L	0071805	biological_process	potassium ion transmembrane transport
L	0086005	biological_process	ventricular cardiac muscle cell action potential
L	0086011	biological_process	membrane repolarization during action potential
L	0086091	biological_process	regulation of heart rate by cardiac conduction
L	0097623	biological_process	potassium ion export across plasma membrane
L	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
L	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
L	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
L	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
L	1905025	biological_process	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
L	1990794	cellular_component	basolateral part of cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue CA B 201

Chain	Residue
B	THR27

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA B 202

Chain	Residue
B	ASP59
B	GLY60
B	ASN61
B	GLY62
B	ILE64

---

site_id	AC3
Number of Residues	1
Details	binding site for residue CA E 201

Chain	Residue
E	THR27

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CA E 202

Chain	Residue
E	ASN61
E	GLY62
E	ILE64
E	ASP59
E	GLY60

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CA H 201

Chain	Residue
H	THR27

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CA H 202

Chain	Residue
H	ASP59
H	GLY60
H	ASN61
H	GLY62
H	ILE64

---

site_id	AC7
Number of Residues	1
Details	binding site for residue CA K 201

Chain	Residue
K	THR27

---

site_id	AC8
Number of Residues	5
Details	binding site for residue CA K 202

Chain	Residue
K	ASP59
K	GLY60
K	ASN61
K	GLY62
K	ILE64

---

site_id	AC9
Number of Residues	10
Details	binding site for residue PT5 J 801

Chain	Residue
J	TYR111
J	ARG116
J	ARG181
J	LYS183
J	ARG195
J	LYS196
J	ILE201
J	GLN244
J	TRP248
L	LYS87

---

site_id	AD1
Number of Residues	10
Details	binding site for residue PT5 A 801

Chain	Residue
A	TYR111
A	ARG116
A	ARG181
A	LYS183
A	ARG195
A	LYS196
A	ILE201
A	GLN244
A	TRP248
C	LYS87

---

site_id	AD2
Number of Residues	10
Details	binding site for residue PT5 D 801

Chain	Residue
D	TYR111
D	ARG116
D	ARG181
D	LYS183
D	ARG195
D	LYS196
D	ILE201
D	GLN244
D	TRP248
F	LYS87

---

site_id	AD3
Number of Residues	10
Details	binding site for residue PT5 G 801

Chain	Residue
G	TYR111
G	ARG116
G	ARG181
G	LYS183
G	ARG195
G	LYS196
G	ILE201
G	GLN244
G	TRP248
I	LYS87

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
B	ASP21-LEU33
B	ASP57-PHE69
B	ASP94-LEU106
B	ASP130-PHE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	TRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:31883792, ECO:0007744|PDB:6V01

Chain	Residue	Details
J	LYS121-LEU142
B	GLU68
E	ASP21
E	ASP23
E	ASP25
E	THR27
E	GLU32
E	ASP57
E	ASP59
E	ASN61
E	THR63
A	LYS121-LEU142
E	GLU68
H	ASP21
H	ASP23
H	ASP25
H	THR27
H	GLU32
H	ASP57
H	ASP59
H	ASN61
H	THR63
D	LYS121-LEU142
H	GLU68
K	ASP21
K	ASP23
K	ASP25
K	THR27
K	GLU32
K	ASP57
K	ASP59
K	ASN61
K	THR63
G	LYS121-LEU142
K	GLU68
B	GLU32
B	ASP57
B	ASP59
B	ASN61
B	THR63

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
J	SER143-THR153
D	GLY219-ALA226
D	GLU284-TYR299
D	GLN321-THR322
G	SER143-THR153
G	GLY219-ALA226
G	GLU284-TYR299
G	GLN321-THR322
K	ASP96
K	ASN98
K	TYR100
J	GLY219-ALA226
K	GLU105
J	GLU284-TYR299
J	GLN321-THR322
A	SER143-THR153
A	GLY219-ALA226
A	GLU284-TYR299
A	GLN321-THR322
D	SER143-THR153

---

site_id	SWS_FT_FI3
Number of Residues	88
Details	TRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:31883792, ECO:0007744|PDB:6V01

Chain	Residue	Details
J	GLY154-TRP176
L	ASN5
L	ASN22
L	ASN41
H	ASP134
H	GLN136
H	GLU141
K	ASP130
K	ASP132
K	ASP134
K	GLN136
A	GLY154-TRP176
K	GLU141
D	GLY154-TRP176
G	GLY154-TRP176
F	ASN22
F	ASN41
I	ASN5
I	ASN22
I	ASN41

---

site_id	SWS_FT_FI4
Number of Residues	128
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
J	SER177-ARG192
J	ARG243-GLN260
A	SER177-ARG192
A	ARG243-GLN260
D	SER177-ARG192
D	ARG243-GLN260
G	SER177-ARG192
G	ARG243-GLN260

---

site_id	SWS_FT_FI5
Number of Residues	100
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:31883792, ECO:0007744|PDB:6V01

Chain	Residue	Details
J	PHE193-LYS218
A	PHE193-LYS218
D	PHE193-LYS218
G	PHE193-LYS218

---

site_id	SWS_FT_FI6
Number of Residues	60
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:31883792, ECO:0007744|PDB:6V01

Chain	Residue	Details
J	ILE227-ASP242
A	ILE227-ASP242
D	ILE227-ASP242
G	ILE227-ASP242

---

site_id	SWS_FT_FI7
Number of Residues	88
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:31883792, ECO:0007744|PDB:6V01

Chain	Residue	Details
J	GLU261-ALA283
A	GLU261-ALA283
D	GLU261-ALA283
G	GLU261-ALA283

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	INTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000269|PubMed:31883792, ECO:0007744|PDB:6V01

Chain	Residue	Details
J	ALA300-PRO320
A	ALA300-PRO320
D	ALA300-PRO320
G	ALA300-PRO320

---

site_id	SWS_FT_FI9
Number of Residues	100
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:31883792, ECO:0007744|PDB:6V01

Chain	Residue	Details
J	TRP323-GLY348
A	TRP323-GLY348
D	TRP323-GLY348
G	TRP323-GLY348

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:31883792, ECO:0007744|PDB:6V01

Chain	Residue	Details
J	GLN244
A	GLN244
D	GLN244
G	GLN244

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97414

Chain	Residue	Details
J	SER407
J	SER409
A	SER407
A	SER409
D	SER407
D	SER409
G	SER407
G	SER409

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
J	ASN289
A	ASN289
D	ASN289
G	ASN289

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
B	TYR139
E	TYR139
H	TYR139
K	TYR139

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
B	LYS22
E	LYS22
H	LYS22
K	LYS22

---