6UZR
Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and homoquinolinic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate receptor ionotropic, NMDA 1 | polymer | 292 | 33340.0 | 1 | UniProt (P35439) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B (B) | Glutamate receptor ionotropic, NMDA 2A | polymer | 282 | 31698.2 | 1 | UniProt (Q00959) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A |
| 3 | C (A) | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
| 4 | D, E, G (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | F (B) | 3-(carboxymethyl)pyridine-2-carboxylic acid | non-polymer | 181.1 | 1 | Chemie (QM1) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 405 | Chemie (HOH) |
Sequence modifications
A: 2 - 152 (UniProt: P35439)
A: 155 - 292 (UniProt: P35439)
B: 5 - 142 (UniProt: Q00959)
B: 145 - 286 (UniProt: Q00959)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 153 | - | linker |
| Thr 154 | - | linker |
B: 145 - 286 (UniProt: Q00959)
| PDB | External Database | Details |
|---|---|---|
| Gly 143 | - | linker |
| Thr 144 | - | linker |
| Thr 242 | Ser 758 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65038.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 532.5 | |
| All* | Total formula weight | 65570.7 |
