6UVP
BACE-1 in complex with compound #3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-secretase 1 | polymer | 442 | 48970.1 | 2 | UniProt (P56817) Pfam (PF00026) | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
| 2 | C, H, I, J (A, B) | N-{(1S,2S)-2-[(4aS,7aR)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]cyclopropyl}-5-fluoropyridine-2-carboxamide | non-polymer | 336.4 | 4 | Chemie (QJJ) | |||
| 3 | D, K (A, B) | N-{(1R,2R)-2-[(4aS,7aR)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]cyclopropyl}-5-fluoropyridine-2-carboxamide | non-polymer | 336.4 | 2 | Chemie (QJM) | |||
| 4 | E, F, L, M (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | G, N, O (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | P, Q (A, B) | water | water | 18.0 | 1104 | Chemie (HOH) |
Sequence modifications
A, B: -47 - 393 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Met -48 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 97940.2 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2674.9 | |
| All* | Total formula weight | 100615.1 |
